↓ Skip to main content

Checks and balances? DNA replication and the cell cycle in Plasmodium

Overview of attention for article published in Parasites & Vectors, March 2018
Altmetric Badge

About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (78th percentile)
  • High Attention Score compared to outputs of the same age and source (83rd percentile)

Mentioned by

twitter
14 X users

Citations

dimensions_citation
94 Dimensions

Readers on

mendeley
200 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Checks and balances? DNA replication and the cell cycle in Plasmodium
Published in
Parasites & Vectors, March 2018
DOI 10.1186/s13071-018-2800-1
Pubmed ID
Authors

Holly Matthews, Craig W. Duffy, Catherine J. Merrick

Abstract

It is over 100 years since the life-cycle of the malaria parasite Plasmodium was discovered, yet its intricacies remain incompletely understood - a knowledge gap that may prove crucial for our efforts to control the disease. Phenotypic screens have partially filled the void in the antimalarial drug market, but as compound libraries eventually become exhausted, new medicines will only come from directed drug development based on a better understanding of fundamental parasite biology. This review focusses on the unusual cell cycles of Plasmodium, which may present a rich source of novel drug targets as well as a topic of fundamental biological interest. Plasmodium does not grow by conventional binary fission, but rather by several syncytial modes of replication including schizogony and sporogony. Here, we collate what is known about the various cell cycle events and their regulators throughout the Plasmodium life-cycle, highlighting the differences between Plasmodium, model organisms and other apicomplexan parasites and identifying areas where further study is required. The possibility of DNA replication and the cell cycle as a drug target is also explored. Finally the use of existing tools, emerging technologies, their limitations and future directions to elucidate the peculiarities of the Plasmodium cell cycle are discussed.

X Demographics

X Demographics

The data shown below were collected from the profiles of 14 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 200 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 200 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 46 23%
Student > Bachelor 30 15%
Student > Master 24 12%
Researcher 19 10%
Student > Postgraduate 6 3%
Other 12 6%
Unknown 63 32%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 60 30%
Agricultural and Biological Sciences 34 17%
Immunology and Microbiology 19 10%
Pharmacology, Toxicology and Pharmaceutical Science 4 2%
Computer Science 4 2%
Other 12 6%
Unknown 67 34%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 March 2021.
All research outputs
#3,744,360
of 25,205,864 outputs
Outputs from Parasites & Vectors
#828
of 5,918 outputs
Outputs of similar age
#71,935
of 335,810 outputs
Outputs of similar age from Parasites & Vectors
#30
of 181 outputs
Altmetric has tracked 25,205,864 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,918 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.1. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 335,810 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 78% of its contemporaries.
We're also able to compare this research output to 181 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.