Title |
A widespread peroxiredoxin-like domain present in tumor suppression- and progression-implicated proteins
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Published in |
BMC Genomics, October 2010
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DOI | 10.1186/1471-2164-11-590 |
Pubmed ID | |
Authors |
Krzysztof Pawłowski, Anna Muszewska, Anna Lenart, Teresa Szczepińska, Adam Godzik, Marcin Grynberg |
Abstract |
Peroxide turnover and signalling are involved in many biological phenomena relevant to human diseases. Yet, all the players and mechanisms involved in peroxide perception are not known. Elucidating very remote evolutionary relationships between proteins is an approach that allows the discovery of novel protein functions. Here, we start with three human proteins, SRPX, SRPX2 and CCDC80, involved in tumor suppression and progression, which possess a conserved region of similarity. Structure and function prediction allowed the definition of P-DUDES, a phylogenetically widespread, possibly ancient protein structural domain, common to vertebrates and many bacterial species. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Netherlands | 1 | 3% |
Unknown | 32 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 12 | 36% |
Student > Ph. D. Student | 6 | 18% |
Professor | 3 | 9% |
Student > Doctoral Student | 2 | 6% |
Student > Bachelor | 2 | 6% |
Other | 4 | 12% |
Unknown | 4 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 8 | 24% |
Agricultural and Biological Sciences | 5 | 15% |
Medicine and Dentistry | 5 | 15% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 9% |
Neuroscience | 2 | 6% |
Other | 4 | 12% |
Unknown | 6 | 18% |