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Targeting APOBEC3A to the viral nucleoprotein complex confers antiviral activity

Overview of attention for article published in Retrovirology, August 2007
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Mentioned by

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1 Wikipedia page

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mendeley
49 Mendeley
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Title
Targeting APOBEC3A to the viral nucleoprotein complex confers antiviral activity
Published in
Retrovirology, August 2007
DOI 10.1186/1742-4690-4-61
Pubmed ID
Authors

Ritu Goila-Gaur, Mohammad A Khan, Eri Miyagi, Sandra Kao, Klaus Strebel

Abstract

APOBEC3 (A3) proteins constitute a family of cytidine deaminases that provide intracellular resistance to retrovirus replication and to transposition of endogenous retroelements. A3A has significant homology to the C-terminus of A3G but has only a single cytidine deaminase active site (CDA), unlike A3G, which has a second N-terminal CDA previously found to be important for Vif sensitivity and virus encapsidation. A3A is packaged into HIV-1 virions but, unlike A3G, does not have antiviral properties. Here, we investigated the reason for the lack of A3A antiviral activity.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 49 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Spain 1 2%
United States 1 2%
France 1 2%
Unknown 45 92%

Demographic breakdown

Readers by professional status Count As %
Researcher 13 27%
Student > Ph. D. Student 11 22%
Student > Bachelor 7 14%
Professor 5 10%
Student > Master 3 6%
Other 4 8%
Unknown 6 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 23 47%
Biochemistry, Genetics and Molecular Biology 9 18%
Immunology and Microbiology 4 8%
Medicine and Dentistry 2 4%
Business, Management and Accounting 1 2%
Other 4 8%
Unknown 6 12%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 January 2008.
All research outputs
#7,454,066
of 22,788,370 outputs
Outputs from Retrovirology
#408
of 1,106 outputs
Outputs of similar age
#24,712
of 68,678 outputs
Outputs of similar age from Retrovirology
#1
of 6 outputs
Altmetric has tracked 22,788,370 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,106 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one has gotten more attention than average, scoring higher than 51% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 68,678 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them