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Mendeley readers
Attention Score in Context
| Title |
DBR1 siRNA inhibition of HIV-1 replication
|
|---|---|
| Published in |
Retrovirology, October 2005
|
| DOI | 10.1186/1742-4690-2-63 |
| Pubmed ID | |
| Authors |
Ying Ye, Jessica De Leon, Noriko Yokoyama, Yathi Naidu, David Camerini |
| Abstract |
HIV-1 and all retroviruses are related to retroelements of simpler organisms such as the yeast Ty elements. Recent work has suggested that the yeast retroelement Ty1 replicates via an unexpected RNA lariat intermediate in cDNA synthesis. The putative genomic RNA lariat intermediate is formed by a 2'-5' phosphodiester bond, like that found in pre-mRNA intron lariats and it facilitates the minus-strand template switch during cDNA synthesis. We hypothesized that HIV-1 might also form a genomic RNA lariat and therefore that siRNA-mediated inhibition of expression of the human RNA lariat de-branching enzyme (DBR1) expression would specifically inhibit HIV-1 replication. |
Mendeley readers
The data shown below were compiled from readership statistics for 49 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 4% |
| Canada | 1 | 2% |
| Unknown | 46 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 14 | 29% |
| Researcher | 10 | 20% |
| Student > Master | 5 | 10% |
| Professor | 3 | 6% |
| Student > Doctoral Student | 3 | 6% |
| Other | 8 | 16% |
| Unknown | 6 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 22 | 45% |
| Biochemistry, Genetics and Molecular Biology | 15 | 31% |
| Chemistry | 2 | 4% |
| Medicine and Dentistry | 2 | 4% |
| Immunology and Microbiology | 1 | 2% |
| Other | 0 | 0% |
| Unknown | 7 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 July 2018.
All research outputs
#7,454,066
of 22,788,370 outputs
Outputs from Retrovirology
#408
of 1,106 outputs
Outputs of similar age
#20,521
of 58,961 outputs
Outputs of similar age from Retrovirology
#2
of 3 outputs
Altmetric has tracked 22,788,370 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,106 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one has gotten more attention than average, scoring higher than 51% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 58,961 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one.