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The integrated stress response regulates BMP signalling through effects on translation

Overview of attention for article published in BMC Biology, April 2018
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (77th percentile)

Mentioned by

twitter
17 tweeters
facebook
1 Facebook page

Citations

dimensions_citation
15 Dimensions

Readers on

mendeley
28 Mendeley
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Title
The integrated stress response regulates BMP signalling through effects on translation
Published in
BMC Biology, April 2018
DOI 10.1186/s12915-018-0503-x
Pubmed ID
Authors

Elke Malzer, Caia S. Dominicus, Joseph E. Chambers, Jennifer A. Dickens, Souradip Mookerjee, Stefan J. Marciniak

Abstract

Developmental pathways must be responsive to the environment. Phosphorylation of eIF2α enables a family of stress-sensing kinases to trigger the integrated stress response (ISR), which has pro-survival and developmental consequences. Bone morphogenetic proteins (BMPs) regulate multiple developmental processes in organisms from insects to mammals. Here we show in Drosophila that GCN2 antagonises BMP signalling through direct effects on translation and indirectly via the transcription factor crc (dATF4). Expression of a constitutively active GCN2 or loss of the eIF2α phosphatase dPPP1R15 impairs developmental BMP signalling in flies. In cells, inhibition of translation by GCN2 blocks downstream BMP signalling. Moreover, loss of d4E-BP, a target of crc, augments BMP signalling in vitro and rescues tissue development in vivo. These results identify a novel mechanism by which the ISR modulates BMP signalling during development.

Twitter Demographics

The data shown below were collected from the profiles of 17 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 28 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 21%
Student > Ph. D. Student 6 21%
Student > Doctoral Student 3 11%
Student > Bachelor 2 7%
Lecturer > Senior Lecturer 1 4%
Other 2 7%
Unknown 8 29%
Readers by discipline Count As %
Agricultural and Biological Sciences 7 25%
Biochemistry, Genetics and Molecular Biology 4 14%
Medicine and Dentistry 2 7%
Neuroscience 2 7%
Physics and Astronomy 1 4%
Other 3 11%
Unknown 9 32%

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 September 2019.
All research outputs
#2,457,359
of 15,916,110 outputs
Outputs from BMC Biology
#669
of 1,363 outputs
Outputs of similar age
#62,291
of 280,826 outputs
Outputs of similar age from BMC Biology
#1
of 2 outputs
Altmetric has tracked 15,916,110 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,363 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 19.6. This one has gotten more attention than average, scoring higher than 50% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,826 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 77% of its contemporaries.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them