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Invasive meningococcal disease due to a non-capsulated Neisseria meningitidis strain in a patient with IgG4-related disease

Overview of attention for article published in BMC Infectious Diseases, April 2018
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Title
Invasive meningococcal disease due to a non-capsulated Neisseria meningitidis strain in a patient with IgG4-related disease
Published in
BMC Infectious Diseases, April 2018
DOI 10.1186/s12879-018-3064-2
Pubmed ID
Authors

Shun Kurose, Kyoko Onozawa, Hiroshi Yoshikawa, Kenichiro Yaita, Hideyuki Takahashi, Nobuyuki Shimono, Yoji Nagasaki

Abstract

Invasive Meningococcal Disease (IMD) is a rare and critical disease in Japan. Most of these cases are caused by capsulated Neisseria meningitidis strains. Non-capsulated (non-typable) strains are considered relatively low-pathogenic and can colonize in the nasopharynx of healthy children and young adults. As far as could be ascertained, only twelve IMD cases due to non-capsulated strains have been reported in the literature. No clear risk factors could be identified in a literature review (unknown or immunocompetent, seven cases; C6 deficiency, three cases). We report a Japanese male taxi driver with bacteremia and meningitis due to non-capsulated N. meningitidis. He had a fever and shaking chills. Ceftriaxone was administered, and the patient finally recovered. During the clinical course, relative adrenal insufficiency occurred and was treated with hydrocortisone. A hidden co-morbidity, immunoglobulin G4 (IgG4)-related disease, was revealed in the past surgical history (a resection of bilateral orbital tumors), which included symptoms (swelling lachrymal glands and lymph nodes), elevated IgG4, immunoglobulin E, and hypocomplementemia. He recovered finally and no recurrence was observed. Our IMD case is the first reported in Japan, where IMD is not considered pandemic. The patient had a history of IgG4-related disease, although we could not establish a clear relationship between the patient's IMD and co-morbidity. A collection of further clinical cases might establish the risk factors and characteristics of IMD that could be caused by this neglected pathogen, non-capsulated N. meningitidis.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 20 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 25%
Other 4 20%
Student > Bachelor 3 15%
Student > Master 2 10%
Professor 1 5%
Other 3 15%
Unknown 2 10%
Readers by discipline Count As %
Medicine and Dentistry 9 45%
Chemical Engineering 2 10%
Unspecified 1 5%
Environmental Science 1 5%
Biochemistry, Genetics and Molecular Biology 1 5%
Other 3 15%
Unknown 3 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 April 2018.
All research outputs
#9,797,687
of 12,781,938 outputs
Outputs from BMC Infectious Diseases
#3,013
of 4,739 outputs
Outputs of similar age
#191,043
of 273,414 outputs
Outputs of similar age from BMC Infectious Diseases
#1
of 1 outputs
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