Title |
The membrane mucin MUC4 is elevated in breast tumor lymph node metastases relative to matched primary tumors and confers aggressive properties to breast cancer cells
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Published in |
Breast Cancer Research, September 2009
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DOI | 10.1186/bcr2364 |
Pubmed ID | |
Authors |
Heather C Workman, Jamie K Miller, Ellen Q Ingalla, Rouminder P Kaur, Diane I Yamamoto, Laurel A Beckett, Lawrence JT Young, Robert D Cardiff, Alexander D Borowsky, Kermit L Carraway, Colleen Sweeney, Kermit L Carraway |
Abstract |
Previous studies indicate that overexpression of the membrane-associated mucin MUC4 is potently anti-adhesive to cultured tumor cells, and suppresses cellular apoptotic response to a variety of insults. Such observations raise the possibility that MUC4 expression could contribute to tumor progression or metastasis, but the potential involvement of MUC4 in breast cancer has not been rigorously assessed. The present study aimed to investigate the expression of the membrane mucin MUC4 in normal breast tissue, primary breast tumors and lymph node metastases, and to evaluate the role of MUC4 in promoting the malignant properties of breast tumor cells. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 3% |
Unknown | 36 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 10 | 27% |
Student > Ph. D. Student | 7 | 19% |
Professor | 4 | 11% |
Student > Bachelor | 3 | 8% |
Student > Master | 3 | 8% |
Other | 7 | 19% |
Unknown | 3 | 8% |
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Pharmacology, Toxicology and Pharmaceutical Science | 2 | 5% |
Other | 3 | 8% |
Unknown | 4 | 11% |