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Modeling autosomal dominant optic atrophy using induced pluripotent stem cells and identifying potential therapeutic targets

Overview of attention for article published in Stem Cell Research & Therapy, January 2016
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  • Above-average Attention Score compared to outputs of the same age (55th percentile)
  • Average Attention Score compared to outputs of the same age and source

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32 Dimensions

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52 Mendeley
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Title
Modeling autosomal dominant optic atrophy using induced pluripotent stem cells and identifying potential therapeutic targets
Published in
Stem Cell Research & Therapy, January 2016
DOI 10.1186/s13287-015-0264-1
Pubmed ID
Authors

Jing Chen, Hamidreza Riazifar, Min-Xin Guan, Taosheng Huang

Abstract

Many retinal degenerative diseases are caused by the loss of retinal ganglion cells (RGCs). Autosomal dominant optic atrophy is the most common hereditary optic atrophy disease and is characterized by central vision loss and degeneration of RGCs. Currently, there is no effective treatment for this group of diseases. However, stem cell therapy holds great potential for replacing lost RGCs of patients. Compared with embryonic stem cells, induced pluripotent stem cells (iPSCs) can be derived from adult somatic cells, and they are associated with fewer ethical concerns and are less prone to immune rejection. In addition, patient-derived iPSCs may provide us with a cellular model for studying the pathogenesis and potential therapeutic agents for optic atrophy. In this study, iPSCs were obtained from patients carrying an OPA1 mutation (OPA1 (+/-) -iPSC) that were diagnosed with optic atrophy. These iPSCs were differentiated into putative RGCs, which were subsequently characterized by using RGC-specific expression markers BRN3a and ISLET-1. Mutant OPA1 (+/-) -iPSCs exhibited significantly more apoptosis and were unable to efficiently differentiate into RGCs. However, with the addition of neural induction medium, Noggin, or estrogen, OPA1 (+/-) -iPSC differentiation into RGCs was promoted. Our results suggest that apoptosis mediated by OPA1 mutations plays an important role in the pathogenesis of optic atrophy, and both noggin and β-estrogen may represent potential therapeutic agents for OPA1-related optic atrophy.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 52 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 19%
Student > Ph. D. Student 9 17%
Student > Master 7 13%
Other 5 10%
Student > Doctoral Student 5 10%
Other 10 19%
Unknown 6 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 10 19%
Biochemistry, Genetics and Molecular Biology 9 17%
Neuroscience 7 13%
Medicine and Dentistry 6 12%
Immunology and Microbiology 3 6%
Other 7 13%
Unknown 10 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 May 2019.
All research outputs
#7,549,344
of 23,031,582 outputs
Outputs from Stem Cell Research & Therapy
#760
of 2,431 outputs
Outputs of similar age
#124,193
of 394,876 outputs
Outputs of similar age from Stem Cell Research & Therapy
#28
of 49 outputs
Altmetric has tracked 23,031,582 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,431 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 394,876 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.
We're also able to compare this research output to 49 others from the same source and published within six weeks on either side of this one. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.