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Silencing of the XAF1 gene by promoter hypermethylation in cancer cells and reactivation to TRAIL-sensitization by IFN-β

Overview of attention for article published in BMC Cancer, March 2007
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Title
Silencing of the XAF1 gene by promoter hypermethylation in cancer cells and reactivation to TRAIL-sensitization by IFN-β
Published in
BMC Cancer, March 2007
DOI 10.1186/1471-2407-7-52
Pubmed ID
Authors

O Cristina Micali, Herman H Cheung, Stéphanie Plenchette, Sandra L Hurley, Peter Liston, Eric C LaCasse, Robert G Korneluk

Abstract

XIAP-associated factor 1 (XAF1) is a putative tumor suppressor that exerts its proapoptotic effects through both caspase-dependent and -independent means. Loss of XAF1 expression through promoter methylation has been implicated in the process of tumorigenesis in a variety of cancers. In this report, we investigated the role of basal xaf1 promoter methylation in xaf1 expression and assessed the responsiveness of cancer cell lines to XAF1 induction by IFN-beta.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 3%
United Kingdom 1 3%
Korea, Republic of 1 3%
Unknown 32 91%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 23%
Researcher 7 20%
Other 4 11%
Student > Master 3 9%
Student > Bachelor 2 6%
Other 7 20%
Unknown 4 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 16 46%
Medicine and Dentistry 7 20%
Biochemistry, Genetics and Molecular Biology 5 14%
Immunology and Microbiology 1 3%
Unspecified 1 3%
Other 2 6%
Unknown 3 9%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 July 2018.
All research outputs
#7,454,066
of 22,788,370 outputs
Outputs from BMC Cancer
#2,059
of 8,294 outputs
Outputs of similar age
#27,152
of 76,882 outputs
Outputs of similar age from BMC Cancer
#7
of 14 outputs
Altmetric has tracked 22,788,370 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 8,294 research outputs from this source. They receive a mean Attention Score of 4.3. This one has gotten more attention than average, scoring higher than 68% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 76,882 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one is in the 7th percentile – i.e., 7% of its contemporaries scored the same or lower than it.