Title |
Promoter methylation-associated loss of ID4expression is a marker of tumour recurrence in human breast cancer
|
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Published in |
BMC Cancer, May 2008
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DOI | 10.1186/1471-2407-8-154 |
Pubmed ID | |
Authors |
Erik Noetzel, Jürgen Veeck, Dieter Niederacher, Oliver Galm, Felicitas Horn, Arndt Hartmann, Ruth Knüchel, Edgar Dahl |
Abstract |
Inhibitor of DNA binding/Inhibitor of differentiation 4 (ID4) is a critical factor for cell proliferation and differentiation in normal vertebrate development. ID4 has regulative functions for differentiation and growth of the developing brain. The role of ID1, ID2 and ID3 are expected to be oncogenic due to their overexpression in pancreatic cancer and colorectal adenocarcinomas, respectively. Aside from these findings, loss of ID3 expression was demonstrated in ovarian cancer. The aim of the present study was to reveal the factual role of ID4 in carcinogenesis in more detail, since its role for the pathogenesis of human breast cancer has been discussed controversially, assigning both oncogenic and tumour suppressive functions. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 2% |
Unknown | 44 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 12 | 27% |
Researcher | 9 | 20% |
Student > Master | 6 | 13% |
Student > Doctoral Student | 3 | 7% |
Professor | 2 | 4% |
Other | 6 | 13% |
Unknown | 7 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 14 | 31% |
Medicine and Dentistry | 14 | 31% |
Biochemistry, Genetics and Molecular Biology | 9 | 20% |
Sports and Recreations | 1 | 2% |
Unknown | 7 | 16% |