Title |
Bisphenol A-associated epigenomic changes in prepubescent girls: a cross-sectional study in Gharbiah, Egypt
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Published in |
Environmental Health, April 2013
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DOI | 10.1186/1476-069x-12-33 |
Pubmed ID | |
Authors |
Jung H Kim, Laura S Rozek, Amr S Soliman, Maureen A Sartor, Ahmed Hablas, Ibrahim A Seifeldin, Justin A Colacino, Caren Weinhouse, Muna S Nahar, Dana C Dolinoy |
Abstract |
There is now compelling evidence that epigenetic modifications link adult disease susceptibility to environmental exposures during specific life stages, including pre-pubertal development. Animal studies indicate that bisphenol A (BPA), the monomer used in epoxy resins and polycarbonate plastics, may impact health through epigenetic mechanisms, and epidemiological data associate BPA levels with metabolic disorders, behavior changes, and reproductive effects. Thus, we conducted an environmental epidemiology study of BPA exposure and CpG methylation in pre-adolescent girls from Gharbiah, Egypt hypothesizing that methylation profiles exhibit exposure-dependent trends. |
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Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 16 | 16% |
Student > Master | 15 | 15% |
Student > Bachelor | 8 | 8% |
Professor | 6 | 6% |
Other | 16 | 16% |
Unknown | 20 | 21% |
Readers by discipline | Count | As % |
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Environmental Science | 7 | 7% |
Nursing and Health Professions | 5 | 5% |
Other | 13 | 13% |
Unknown | 27 | 28% |