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Expression profiling of serum inducible genes identifies a subset of SRF target genes that are MKL dependent

Overview of attention for article published in BMC Molecular and Cell Biology, August 2004
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Title
Expression profiling of serum inducible genes identifies a subset of SRF target genes that are MKL dependent
Published in
BMC Molecular and Cell Biology, August 2004
DOI 10.1186/1471-2199-5-13
Pubmed ID
Authors

Ahalya Selvaraj, Ron Prywes

Abstract

Serum Response Factor (SRF) is a transcription factor that is required for the expression of many genes including immediate early genes, cytoskeletal genes, and muscle-specific genes. SRF is activated in response to extra-cellular signals by its association with a diverse set of co-activators in different cell types. In the case of the ubiquitously expressed immediate early genes, the two sets of SRF binding proteins that regulate its activity are the TCF family of proteins that include Elk1, SAP1 and SAP2 and the myocardin-related MKL family of proteins that include MKL1 and MKL2 (also known as MAL, MRTF-A and -B and BSAC). In response to serum or growth factors these two classes of co-activators are activated by different upstream signal transduction pathways. However, it is not clear how they differentially activate SRF target genes.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 85 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 2 2%
United Kingdom 1 1%
Spain 1 1%
France 1 1%
Unknown 80 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 23 27%
Researcher 19 22%
Student > Bachelor 10 12%
Student > Master 5 6%
Student > Doctoral Student 4 5%
Other 12 14%
Unknown 12 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 39 46%
Biochemistry, Genetics and Molecular Biology 21 25%
Medicine and Dentistry 7 8%
Physics and Astronomy 2 2%
Engineering 2 2%
Other 3 4%
Unknown 11 13%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 July 2018.
All research outputs
#8,534,976
of 25,373,627 outputs
Outputs from BMC Molecular and Cell Biology
#334
of 1,233 outputs
Outputs of similar age
#22,539
of 67,923 outputs
Outputs of similar age from BMC Molecular and Cell Biology
#6
of 13 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,233 research outputs from this source. They receive a mean Attention Score of 4.0. This one is in the 48th percentile – i.e., 48% of its peers scored the same or lower than it.
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We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.