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Evaluation of the OPTC gene in primary open angle glaucoma: functional significance of a silent change

Overview of attention for article published in BMC Molecular and Cell Biology, March 2007
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2 Wikipedia pages

Citations

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27 Dimensions

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23 Mendeley
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Title
Evaluation of the OPTC gene in primary open angle glaucoma: functional significance of a silent change
Published in
BMC Molecular and Cell Biology, March 2007
DOI 10.1186/1471-2199-8-21
Pubmed ID
Authors

Moulinath Acharya, Suddhasil Mookherjee, Ashima Bhattacharjee, Sanjay KD Thakur, Arun K Bandyopadhyay, Abhijit Sen, Subhabrata Chakrabarti, Kunal Ray

Abstract

We investigated the molecular basis of primary open-angle glaucoma (POAG) using Opticin (OPTC) as a candidate gene on the basis of its expression in the trabecular meshwork cells involved in the disease pathogenesis. Two hundred POAG patients and 100 controls were enrolled in this study. The coding sequence of OPTC was amplified by PCR from genomic DNA of POAG patients, followed by SSCP, DHPLC and DNA sequencing. Subsequent bioinformatic analysis, site-directed mutagenesis, quantitative RT-PCR and western blot experiments were performed to address the functional significance of a 'silent' change in the OPTC coding region while screening for mutations in POAG patients.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Malaysia 1 4%
Unknown 22 96%

Demographic breakdown

Readers by professional status Count As %
Professor 4 17%
Student > Bachelor 3 13%
Researcher 3 13%
Student > Ph. D. Student 2 9%
Student > Master 2 9%
Other 2 9%
Unknown 7 30%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 10 43%
Medicine and Dentistry 4 17%
Agricultural and Biological Sciences 2 9%
Unknown 7 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 July 2018.
All research outputs
#8,534,976
of 25,373,627 outputs
Outputs from BMC Molecular and Cell Biology
#334
of 1,233 outputs
Outputs of similar age
#32,043
of 89,739 outputs
Outputs of similar age from BMC Molecular and Cell Biology
#4
of 13 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,233 research outputs from this source. They receive a mean Attention Score of 4.0. This one is in the 48th percentile – i.e., 48% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 89,739 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.