Title |
An integrative computational systems biology approach identifies differentially regulated dynamic transcriptome signatures which drive the initiation of human T helper cell differentiation
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Published in |
BMC Genomics, October 2012
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DOI | 10.1186/1471-2164-13-572 |
Pubmed ID | |
Authors |
Tarmo Äijö, Sanna M Edelman, Tapio Lönnberg, Antti Larjo, Henna Kallionpää, Soile Tuomela, Emilia Engström, Riitta Lahesmaa, Harri Lähdesmäki |
Abstract |
A proper balance between different T helper (Th) cell subsets is necessary for normal functioning of the adaptive immune system. Revealing key genes and pathways driving the differentiation to distinct Th cell lineages provides important insight into underlying molecular mechanisms and new opportunities for modulating the immune response. Previous computational methods to quantify and visualize kinetic differential expression data of three or more lineages to identify reciprocally regulated genes have relied on clustering approaches and regression methods which have time as a factor, but have lacked methods which explicitly model temporal behavior. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 2 | 4% |
Luxembourg | 1 | 2% |
Unknown | 46 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 13 | 27% |
Researcher | 12 | 24% |
Student > Postgraduate | 4 | 8% |
Student > Master | 4 | 8% |
Student > Bachelor | 3 | 6% |
Other | 6 | 12% |
Unknown | 7 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 16 | 33% |
Biochemistry, Genetics and Molecular Biology | 7 | 14% |
Immunology and Microbiology | 6 | 12% |
Computer Science | 4 | 8% |
Medicine and Dentistry | 3 | 6% |
Other | 4 | 8% |
Unknown | 9 | 18% |