Title |
Requirements for activation and RAFT localization of the T-lymphocyte kinase Rlk/Txk
|
---|---|
Published in |
BMC Immunology, May 2001
|
DOI | 10.1186/1471-2172-2-3 |
Pubmed ID | |
Authors |
Mario Chamorro, Michael J Czar, Jayanta Debnath, Genhong Cheng, Michael J Lenardo, Harold E Varmus, Pamela L Schwartzberg |
Abstract |
The Tec family kinases are implicated in signaling from lymphocyte antigen receptors and are activated following phosphorylation by Src kinases. For most Tec kinases, this activation requires an interaction between their pleckstrin homology (PH) domains and the products of phosphoinositide 3-Kinase, which localizes Tec kinases to membrane RAFTs. Rlk/Txk is a Tec related kinase expressed in T cells that lacks a pleckstrin homology domain, having instead a palmitoylated cysteine-string motif. To evaluate Rlk's function in T cell receptor signaling cascades, we examined the requirements for Rlk localization and activation by Src family kinases. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 22 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 9 | 41% |
Student > Ph. D. Student | 4 | 18% |
Other | 2 | 9% |
Student > Doctoral Student | 2 | 9% |
Student > Bachelor | 1 | 5% |
Other | 1 | 5% |
Unknown | 3 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 10 | 45% |
Biochemistry, Genetics and Molecular Biology | 3 | 14% |
Medicine and Dentistry | 2 | 9% |
Immunology and Microbiology | 1 | 5% |
Engineering | 1 | 5% |
Other | 0 | 0% |
Unknown | 5 | 23% |