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The mRNA expression of SETD2 in human breast cancer: correlation with clinico-pathological parameters

Overview of attention for article published in BMC Cancer, August 2009
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (66th percentile)
  • Good Attention Score compared to outputs of the same age and source (75th percentile)

Mentioned by

wikipedia
3 Wikipedia pages

Citations

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84 Dimensions

Readers on

mendeley
65 Mendeley
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Title
The mRNA expression of SETD2 in human breast cancer: correlation with clinico-pathological parameters
Published in
BMC Cancer, August 2009
DOI 10.1186/1471-2407-9-290
Pubmed ID
Authors

W Al Sarakbi, W Sasi, WG Jiang, T Roberts, RF Newbold, K Mokbel

Abstract

SET domain containing protein 2 (SETD2) is a histone methyltransferase that is involved in transcriptional elongation. There is evidence that SETD2 interacts with p53 and selectively regulates its downstream genes. Therefore, it could be implicated in the process of carcinogenesis. Furthermore, this gene is located on the short arm of chromosome 3p and we previously demonstrated that the 3p21.31 region of chromosome 3 was associated with permanent growth arrest of breast cancer cells. This region includes closely related genes namely: MYL3, CCDC12, KIF9, KLHL18 and SETD2. Based on the biological function of these genes, SETD2 is the most likely gene to play a tumour suppressor role and explain our previous findings. Our objective was to determine, using quantitative PCR, whether the mRNA expression levels of SETD2 were consistent with a tumour suppressive function in breast cancer. This is the first study in the literature to examine the direct relationship between SETD2 and breast cancer.

Mendeley readers

The data shown below were compiled from readership statistics for 65 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Portugal 1 2%
Poland 1 2%
Unknown 63 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 21 32%
Researcher 13 20%
Student > Master 10 15%
Student > Bachelor 7 11%
Student > Doctoral Student 3 5%
Other 9 14%
Unknown 2 3%
Readers by discipline Count As %
Agricultural and Biological Sciences 28 43%
Biochemistry, Genetics and Molecular Biology 19 29%
Medicine and Dentistry 9 14%
Immunology and Microbiology 1 2%
Neuroscience 1 2%
Other 0 0%
Unknown 7 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 June 2019.
All research outputs
#3,577,265
of 12,372,945 outputs
Outputs from BMC Cancer
#969
of 4,558 outputs
Outputs of similar age
#79,404
of 268,223 outputs
Outputs of similar age from BMC Cancer
#4
of 16 outputs
Altmetric has tracked 12,372,945 research outputs across all sources so far. This one is in the 49th percentile – i.e., 49% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,558 research outputs from this source. They receive a mean Attention Score of 3.9. This one has gotten more attention than average, scoring higher than 71% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 268,223 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.