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The mRNA expression of SETD2 in human breast cancer: correlation with clinico-pathological parameters

Overview of attention for article published in BMC Cancer, August 2009
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3 Wikipedia pages

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Title
The mRNA expression of SETD2 in human breast cancer: correlation with clinico-pathological parameters
Published in
BMC Cancer, August 2009
DOI 10.1186/1471-2407-9-290
Pubmed ID
Authors

W Al Sarakbi, W Sasi, WG Jiang, T Roberts, RF Newbold, K Mokbel

Abstract

SET domain containing protein 2 (SETD2) is a histone methyltransferase that is involved in transcriptional elongation. There is evidence that SETD2 interacts with p53 and selectively regulates its downstream genes. Therefore, it could be implicated in the process of carcinogenesis. Furthermore, this gene is located on the short arm of chromosome 3p and we previously demonstrated that the 3p21.31 region of chromosome 3 was associated with permanent growth arrest of breast cancer cells. This region includes closely related genes namely: MYL3, CCDC12, KIF9, KLHL18 and SETD2. Based on the biological function of these genes, SETD2 is the most likely gene to play a tumour suppressor role and explain our previous findings. Our objective was to determine, using quantitative PCR, whether the mRNA expression levels of SETD2 were consistent with a tumour suppressive function in breast cancer. This is the first study in the literature to examine the direct relationship between SETD2 and breast cancer.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 71 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Portugal 1 1%
Unknown 70 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 21 30%
Researcher 13 18%
Student > Master 10 14%
Student > Bachelor 7 10%
Student > Doctoral Student 3 4%
Other 10 14%
Unknown 7 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 28 39%
Biochemistry, Genetics and Molecular Biology 20 28%
Medicine and Dentistry 9 13%
Immunology and Microbiology 1 1%
Neuroscience 1 1%
Other 0 0%
Unknown 12 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 June 2019.
All research outputs
#7,454,298
of 22,789,076 outputs
Outputs from BMC Cancer
#2,059
of 8,294 outputs
Outputs of similar age
#36,096
of 105,908 outputs
Outputs of similar age from BMC Cancer
#18
of 42 outputs
Altmetric has tracked 22,789,076 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 8,294 research outputs from this source. They receive a mean Attention Score of 4.3. This one has gotten more attention than average, scoring higher than 68% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 105,908 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 19th percentile – i.e., 19% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 42 others from the same source and published within six weeks on either side of this one. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.