Title |
The expression of the ubiquitin ligase subunit Cks1 in human breast cancer
|
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Published in |
Breast Cancer Research, July 2005
|
DOI | 10.1186/bcr1278 |
Pubmed ID | |
Authors |
Merav Slotky, Ma'anit Shapira, Ofer Ben-Izhak, Shai Linn, Boris Futerman, Medy Tsalic, Dan D Hershko |
Abstract |
Loss of the cell-cycle inhibitory protein p27Kip1 is associated with a poor prognosis in breast cancer. The decrease in the levels of this protein is the result of increased proteasome-dependent degradation, mediated and rate-limited by its specific ubiquitin ligase subunits S-phase kinase protein 2 (Skp2) and cyclin-dependent kinase subunit 1 (Cks1). Skp2 was recently found to be overexpressed in breast cancers, but the role of Cks1 in these cancers is unknown. The present study was undertaken to examine the role of Cks1 expression in breast cancer and its relation to p27Kip1 and Skp2 expression and to tumor aggressiveness. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | 4% |
Unknown | 22 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 10 | 43% |
Professor | 3 | 13% |
Student > Bachelor | 3 | 13% |
Student > Master | 2 | 9% |
Researcher | 1 | 4% |
Other | 0 | 0% |
Unknown | 4 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 5 | 22% |
Medicine and Dentistry | 5 | 22% |
Biochemistry, Genetics and Molecular Biology | 2 | 9% |
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Chemistry | 2 | 9% |
Other | 3 | 13% |
Unknown | 4 | 17% |