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At $RIGL '99-02 I did a TRA-cDNA screen for modulators of Jurkat CD69 (collab for $NVS). Dominant negative EDG1 aka S1P1 was a top hit. We nominated it to $NVS as a new target. $NVS was already working on FTY720 Fingolimod Gilenya (approved 2010) https://t