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Rapid intracerebroventricular delivery of Cu-DOTA-etanercept after peripheral administration demonstrated by PET imaging

Overview of attention for article published in BMC Research Notes, February 2009
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Title
Rapid intracerebroventricular delivery of Cu-DOTA-etanercept after peripheral administration demonstrated by PET imaging
Published in
BMC Research Notes, February 2009
DOI 10.1186/1756-0500-2-28
Pubmed ID
Authors

Edward L Tobinick, Kai Chen, Xiaoyuan Chen

Abstract

The cytokines interleukin-1 and tumor necrosis factor (TNF), and the cytokine blocker interleukin-1 receptor antagonist, all have been demonstrated to enter the cerebrospinal fluid (CSF) following peripheral administration. Recent reports of rapid clinical improvement in patients with Alzheimer's disease and related forms of dementia following perispinal administration of etanercept, a TNF antagonist, suggest that etanercept also has the ability to reach the brain CSF. To investigate, etanercept was labeled with a positron emitter to enable visualization of its intracranial distribution following peripheral administration by PET in an animal model.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 24 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 5 21%
Student > Ph. D. Student 4 17%
Researcher 4 17%
Professor 3 13%
Other 2 8%
Other 5 21%
Unknown 1 4%
Readers by discipline Count As %
Agricultural and Biological Sciences 5 21%
Medicine and Dentistry 4 17%
Neuroscience 4 17%
Biochemistry, Genetics and Molecular Biology 3 13%
Chemistry 2 8%
Other 2 8%
Unknown 4 17%