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Mendeley readers
Title |
Rapid intracerebroventricular delivery of Cu-DOTA-etanercept after peripheral administration demonstrated by PET imaging
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Published in |
BMC Research Notes, February 2009
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DOI | 10.1186/1756-0500-2-28 |
Pubmed ID | |
Authors |
Edward L Tobinick, Kai Chen, Xiaoyuan Chen |
Abstract |
The cytokines interleukin-1 and tumor necrosis factor (TNF), and the cytokine blocker interleukin-1 receptor antagonist, all have been demonstrated to enter the cerebrospinal fluid (CSF) following peripheral administration. Recent reports of rapid clinical improvement in patients with Alzheimer's disease and related forms of dementia following perispinal administration of etanercept, a TNF antagonist, suggest that etanercept also has the ability to reach the brain CSF. To investigate, etanercept was labeled with a positron emitter to enable visualization of its intracranial distribution following peripheral administration by PET in an animal model. |
Mendeley readers
The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 24 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 5 | 21% |
Student > Ph. D. Student | 4 | 17% |
Researcher | 4 | 17% |
Professor | 3 | 13% |
Other | 2 | 8% |
Other | 5 | 21% |
Unknown | 1 | 4% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 5 | 21% |
Medicine and Dentistry | 4 | 17% |
Neuroscience | 4 | 17% |
Biochemistry, Genetics and Molecular Biology | 3 | 13% |
Chemistry | 2 | 8% |
Other | 2 | 8% |
Unknown | 4 | 17% |