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Synthetic lethal RNAi screening identifies sensitizing targets for gemcitabine therapy in pancreatic cancer

Overview of attention for article published in Journal of Translational Medicine, June 2009
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1 Wikipedia page

Citations

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90 Dimensions

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112 Mendeley
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Title
Synthetic lethal RNAi screening identifies sensitizing targets for gemcitabine therapy in pancreatic cancer
Published in
Journal of Translational Medicine, June 2009
DOI 10.1186/1479-5876-7-43
Pubmed ID
Authors

David O Azorsa, Irma M Gonzales, Gargi D Basu, Ashish Choudhary, Shilpi Arora, Kristen M Bisanz, Jeffrey A Kiefer, Meredith C Henderson, Jeffrey M Trent, Daniel D Von Hoff, Spyro Mousses

Abstract

Pancreatic cancer retains a poor prognosis among the gastrointestinal cancers. It affects 230,000 individuals worldwide, has a very high mortality rate, and remains one of the most challenging malignancies to treat successfully. Treatment with gemcitabine, the most widely used chemotherapeutic against pancreatic cancer, is not curative and resistance may occur. Combinations of gemcitabine with other chemotherapeutic drugs or biological agents have resulted in limited improvement.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 112 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 5 4%
United Kingdom 1 <1%
Italy 1 <1%
Germany 1 <1%
Unknown 104 93%

Demographic breakdown

Readers by professional status Count As %
Researcher 46 41%
Student > Ph. D. Student 18 16%
Student > Master 8 7%
Student > Doctoral Student 7 6%
Professor 6 5%
Other 19 17%
Unknown 8 7%
Readers by discipline Count As %
Agricultural and Biological Sciences 52 46%
Biochemistry, Genetics and Molecular Biology 25 22%
Medicine and Dentistry 12 11%
Pharmacology, Toxicology and Pharmaceutical Science 4 4%
Chemistry 4 4%
Other 7 6%
Unknown 8 7%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 April 2011.
All research outputs
#7,454,298
of 22,789,076 outputs
Outputs from Journal of Translational Medicine
#1,235
of 3,988 outputs
Outputs of similar age
#38,119
of 112,549 outputs
Outputs of similar age from Journal of Translational Medicine
#8
of 16 outputs
Altmetric has tracked 22,789,076 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,988 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.5. This one has gotten more attention than average, scoring higher than 64% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 112,549 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.