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Rheumatoid arthritis specific anti-Sa antibodies target citrullinated vimentin

Overview of attention for article published in Arthritis Research & Therapy, February 2004
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (90th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

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6 patents
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3 Wikipedia pages

Citations

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383 Dimensions

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105 Mendeley
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Title
Rheumatoid arthritis specific anti-Sa antibodies target citrullinated vimentin
Published in
Arthritis Research & Therapy, February 2004
DOI 10.1186/ar1149
Pubmed ID
Authors

Erik R Vossenaar, Normand Després, Elvy Lapointe, Annemarie van der Heijden, Maximillian Lora, Tatsuo Senshu, Walther J van Venrooij, Henri A Ménard

Abstract

Antibodies directed to the Sa antigen are highly specific for rheumatoid arthritis (RA) and can be detected in approximately 40% of RA sera. The antigen, a doublet of protein bands of about 50 kDa, is present in placenta and in RA synovial tissue. Although it has been stated that the Sa antigen is citrullinated vimentin, experimental proof for this claim has never been published. In this study, we investigated the precise nature of the antigen. Peptide sequences that were obtained from highly purified Sa antigen were unique to vimentin. Recombinant vimentin, however, was not recognized by anti-Sa reference sera. In vivo, vimentin is subjected to various post-translational modifications, including citrullination. Since antibodies to citrullinated proteins are known to be highly specific for RA, we investigated whether Sa is citrullinated and found that Sa indeed is citrullinated vimentin. Anti-Sa antibodies thus belong to the family of anticitrullinated protein/peptide antibodies. The presence of the Sa antigen in RA synovial tissue, and the recent observation that vimentin is citrullinated in dying human macrophages, make citrullinated vimentin an interesting candidate autoantigen in RA and may provide new insights into the potential role of citrullinated synovial antigens and the antibodies directed to them in the pathophysiology of RA.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 105 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Hungary 1 <1%
Colombia 1 <1%
Germany 1 <1%
Ireland 1 <1%
Egypt 1 <1%
Mexico 1 <1%
Denmark 1 <1%
United States 1 <1%
Unknown 97 92%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 24 23%
Researcher 23 22%
Student > Bachelor 12 11%
Student > Master 11 10%
Professor > Associate Professor 6 6%
Other 15 14%
Unknown 14 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 30 29%
Medicine and Dentistry 24 23%
Immunology and Microbiology 14 13%
Biochemistry, Genetics and Molecular Biology 11 10%
Pharmacology, Toxicology and Pharmaceutical Science 3 3%
Other 5 5%
Unknown 18 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 April 2021.
All research outputs
#3,823,715
of 25,498,750 outputs
Outputs from Arthritis Research & Therapy
#905
of 3,394 outputs
Outputs of similar age
#10,232
of 146,932 outputs
Outputs of similar age from Arthritis Research & Therapy
#1
of 9 outputs
Altmetric has tracked 25,498,750 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,394 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.2. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 146,932 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them