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Nest expansion assay: a cancer systems biology approach to in vitro invasion measurements

Overview of attention for article published in BMC Research Notes, July 2009
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (72nd percentile)
  • Above-average Attention Score compared to outputs of the same age and source (63rd percentile)

Mentioned by

patent
1 patent
wikipedia
2 Wikipedia pages

Citations

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27 Dimensions

Readers on

mendeley
39 Mendeley
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Title
Nest expansion assay: a cancer systems biology approach to in vitro invasion measurements
Published in
BMC Research Notes, July 2009
DOI 10.1186/1756-0500-2-130
Pubmed ID
Authors

Yoonseok Kam, Audrey Karperien, Brandy Weidow, Lourdes Estrada, Alexander R Anderson, Vito Quaranta

Abstract

Traditional in vitro cell invasion assays focus on measuring one cell parameter at a time and are often less than ideal in terms of reproducibility and quantification. Further, many techniques are not suitable for quantifying the advancing margin of collectively migrating cells, arguably the most important area of activity during tumor invasion. We have developed and applied a highly quantitative, standardized, reproducible Nest Expansion Assay (NEA) to measure cancer cell invasion in vitro, which builds upon established wound-healing techniques. This assay involves creating uniform circular "nests" of cells within a monolayer of cells using a stabilized, silicone-tipped drill press, and quantifying the margin expansion into an overlaid extracellular matrix (ECM)-like component using computer-assisted applications.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Taiwan 1 3%
Unknown 38 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 14 36%
Researcher 5 13%
Student > Master 4 10%
Student > Bachelor 3 8%
Professor > Associate Professor 2 5%
Other 5 13%
Unknown 6 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 9 23%
Engineering 8 21%
Biochemistry, Genetics and Molecular Biology 7 18%
Computer Science 2 5%
Medicine and Dentistry 2 5%
Other 3 8%
Unknown 8 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 December 2023.
All research outputs
#5,446,629
of 25,373,627 outputs
Outputs from BMC Research Notes
#840
of 4,513 outputs
Outputs of similar age
#23,000
of 122,628 outputs
Outputs of similar age from BMC Research Notes
#6
of 22 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,513 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.1. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 122,628 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.