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Characterization of a novel sugar transporter involved in sugarcane bagasse degradation in Trichoderma reesei

Overview of attention for article published in Biotechnology for Biofuels, April 2018
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Title
Characterization of a novel sugar transporter involved in sugarcane bagasse degradation in Trichoderma reesei
Published in
Biotechnology for Biofuels, April 2018
DOI 10.1186/s13068-018-1084-1
Pubmed ID
Authors

Karoline M. V. Nogueira, Renato Graciano de Paula, Amanda Cristina Campos Antoniêto, Thaila F. dos Reis, Cláudia Batista Carraro, Alinne Costa Silva, Fausto Almeida, Carem Gledes Vargas Rechia, Gustavo H. Goldman, Roberto N. Silva

Abstract

Trichoderma reesei is a saprophytic fungus implicated in the degradation of polysaccharides present in the cell wall of plants.T. reeseihas been recognized as the most important industrial fungus that secretes and produces cellulase enzymes that are employed in the production of second generation bioethanol. A few of the molecular mechanisms involved in the process of biomass deconstruction byT. reesei; in particular, the effect of sugar transporters and induction of xylanases and cellulases expression are yet to be known. In our study, we characterized a novel sugar transporter, which was previously identified by our group through in silico analysis of RNA-seq data. The novelT. reesei69957-sugar transport system (Tr69957) is capable of transporting xylose, mannose, and cellobiose using aT. reesei69957-sugar transport system inSaccharomyces cerevisiae. The deletion ofTr69957inT. reeseiaffected the fungal growth and biomass accumulation, and the sugar uptake in the presence of mannose, cellobiose, and xylose. Molecular docking studies revealed thatTr69957shows reduced protein-ligand binding energy for interactions towards disaccharides in comparison with monosaccharides. Furthermore, the deletion ofTr69957affected the gene expression of cellobiohydrolases (cel7aandcel6a), β-glucosidases (cel3aandcel1a), and xylanases (xyn1andxyn2) in the cultures of parental and mutant strains in the presence of cellobiose and sugarcane bagasse (SCB). The transporterTr69957ofT. reeseican transport cellobiose, xylose, and mannose, and can affect the expression of a few genes encoding enzymes, such as cellulases and xylanases, in the presence of SCB. We showed for the first time that a filamentous fungus (T. reesei) contains a potential mannose transporter that may be involved in the degradation of cellulose.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 67 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 67 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 16 24%
Student > Master 10 15%
Researcher 8 12%
Student > Doctoral Student 5 7%
Student > Bachelor 5 7%
Other 8 12%
Unknown 15 22%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 25 37%
Agricultural and Biological Sciences 15 22%
Chemical Engineering 3 4%
Nursing and Health Professions 1 1%
Environmental Science 1 1%
Other 3 4%
Unknown 19 28%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 April 2018.
All research outputs
#13,222,146
of 16,638,522 outputs
Outputs from Biotechnology for Biofuels
#882
of 1,211 outputs
Outputs of similar age
#213,491
of 283,713 outputs
Outputs of similar age from Biotechnology for Biofuels
#1
of 1 outputs
Altmetric has tracked 16,638,522 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,211 research outputs from this source. They receive a mean Attention Score of 4.4. This one is in the 14th percentile – i.e., 14% of its peers scored the same or lower than it.
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