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First molecular detection and characterization of Marek’s disease virus in red-crowned cranes (Grus japonensis): a case report

Overview of attention for article published in BMC Veterinary Research, April 2018
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Title
First molecular detection and characterization of Marek’s disease virus in red-crowned cranes (Grus japonensis): a case report
Published in
BMC Veterinary Research, April 2018
DOI 10.1186/s12917-018-1437-9
Pubmed ID
Authors

Xue Lian, Xin Ming, Jiarong Xu, Wangkun Cheng, Xunhai Zhang, Hongjun Chen, Chan Ding, Yong-Sam Jung, Yingjuan Qian

Abstract

Marek's disease virus (MDV) resides in the genus Mardivirus in the family Herpesviridae. MDV is a highly contagious virus that can cause neurological lesions, lymphocytic proliferation, immune suppression, and death in avian species, including Galliformes (chickens, quails, partridges, and pheasants), Strigiformes (owls), Anseriformes (ducks, geese, and swans), and Falconiformes (kestrels). In 2015, two red-crowned cranes died in Nanjing (Jiangsu, China). It was determined that the birds were infected with Marek's disease virus by histopathological examination, polymerase chain reaction (PCR), gene sequencing and sequence analysis of tissue samples from two cranes. Gross lesions included diffuse nodules in the skin, muscle, liver, spleen, kidney, gizzard and heart, along with liver enlargement and gizzard mucosa hemorrhage. Histopathological assay showed that infiltrative lymphocytes and mitotic figures existed in liver and heart. The presence of MDV was confirmed by PCR. The sequence analysis of the Meq gene showed 100% identity with Md5, while the VP22 gene showed the highest homology with CVI988. Furthermore, the phylogenetic analysis of the VP22 and Meq genes suggested that the MDV (from cranes) belongs to MDV serotype 1. We describe the first molecular detection of Marek's disease in red-crowned cranes based on the findings previously described. To our knowledge, this is also the first molecular identification of Marek's disease virus in the order Gruiformes and represents detection of a novel MDV strain.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 23 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 22%
Student > Master 4 17%
Student > Bachelor 3 13%
Student > Postgraduate 3 13%
Other 1 4%
Other 0 0%
Unknown 7 30%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 8 35%
Biochemistry, Genetics and Molecular Biology 3 13%
Medicine and Dentistry 2 9%
Decision Sciences 1 4%
Materials Science 1 4%
Other 0 0%
Unknown 8 35%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 September 2018.
All research outputs
#13,667,957
of 23,578,918 outputs
Outputs from BMC Veterinary Research
#899
of 3,103 outputs
Outputs of similar age
#166,987
of 330,061 outputs
Outputs of similar age from BMC Veterinary Research
#28
of 102 outputs
Altmetric has tracked 23,578,918 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,103 research outputs from this source. They receive a mean Attention Score of 4.1. This one has gotten more attention than average, scoring higher than 69% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 330,061 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 102 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.