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Alpha-lipoic acid treatment is neurorestorative and promotes functional recovery after stroke in rats

Overview of attention for article published in Molecular Brain, February 2015
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#21 of 1,198)
  • High Attention Score compared to outputs of the same age (96th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Mentioned by

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3 news outlets
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30 X users
facebook
1 Facebook page
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1 YouTube creator

Citations

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35 Dimensions

Readers on

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56 Mendeley
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Title
Alpha-lipoic acid treatment is neurorestorative and promotes functional recovery after stroke in rats
Published in
Molecular Brain, February 2015
DOI 10.1186/s13041-015-0101-6
Pubmed ID
Authors

Kang-Ho Choi, Man-Seok Park, Hyung-Seok Kim, Kyung-Tae Kim, Hyeon-Sik Kim, Joon-Tae Kim, Byeong-Chae Kim, Myeong-Kyu Kim, Jong-Tae Park, Ki-Hyun Cho

Abstract

The antioxidant properties of alpha-lipoic acid (aLA) correlate with its ability to promote neuroproliferation. However, there have been no comprehensive studies examining the neurorestorative effects of aLA administration after the onset of ischemia. The middle cerebral artery (MCA) of adult rats was occluded for 2 hours and then reperfused. aLA (20 mg/kg) was administered in 71 animals (aLA group) through the left external jugular vein immediately after reperfusion. An equivalent volume of vehicle was administered to 71 animals (control group). Functional outcome, levels of endogenous neural precursors with neurogenesis, glial cell activation, and brain metabolism were evaluated. Immediate aLA administration after reperfusion resulted in significantly reduced mortality, infarct size, and neurological deficit score (NDS) in the test group compared to the control group. Long-term functional outcomes, measured by the rotarod test, were markedly improved by aLA treatment. There was a significant increase in the number of cells expressing nestin and GFAP in the boundary zone and infarct core regions after aLA treatment. Furthermore, significantly more BrdU/GFAP, BrdU/DCX, and BrdU/NeuN double-labeled cells were observed along the boundary zone of the aLA group on days 7, 14, and 28 days, respectively. And brain metabolism using 18F-FDG microPET imaging was markedly improved in aLA group. The effects of aLA was blocked by insulin receptor inhibitor, HNMPA (AM)3. These results indicate that immediate treatment with aLA after ischemic injury may have significant neurorestorative effects mediated at least partially via insulin receptor activation. Thus, aLA may be useful for the treatment of acute ischemic stroke.

X Demographics

X Demographics

The data shown below were collected from the profiles of 30 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 56 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 56 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 14%
Student > Bachelor 8 14%
Student > Doctoral Student 6 11%
Other 3 5%
Student > Master 3 5%
Other 11 20%
Unknown 17 30%
Readers by discipline Count As %
Medicine and Dentistry 7 13%
Pharmacology, Toxicology and Pharmaceutical Science 5 9%
Agricultural and Biological Sciences 5 9%
Engineering 4 7%
Psychology 3 5%
Other 16 29%
Unknown 16 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 44. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 August 2023.
All research outputs
#937,183
of 25,362,919 outputs
Outputs from Molecular Brain
#21
of 1,198 outputs
Outputs of similar age
#12,884
of 367,163 outputs
Outputs of similar age from Molecular Brain
#1
of 22 outputs
Altmetric has tracked 25,362,919 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,198 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.9. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 367,163 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.