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Modulations in the offspring gut microbiome are refractory to postnatal synbiotic supplementation among juvenile primates

Overview of attention for article published in BMC Microbiology, April 2018
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  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (79th percentile)
  • High Attention Score compared to outputs of the same age and source (86th percentile)

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Title
Modulations in the offspring gut microbiome are refractory to postnatal synbiotic supplementation among juvenile primates
Published in
BMC Microbiology, April 2018
DOI 10.1186/s12866-018-1169-9
Pubmed ID
Authors

Ryan M. Pace, Amanda L. Prince, Jun Ma, Benjamin D. W. Belfort, Alexia S. Harvey, Min Hu, Karalee Baquero, Peter Blundell, Diana Takahashi, Tyler Dean, Paul Kievit, Elinor L. Sullivan, Jacob E. Friedman, Kevin Grove, Kjersti M. Aagaard

Abstract

We and others have previously shown that alterations in the mammalian gut microbiome are associated with diet, notably early life exposure to a maternal high fat diet (HFD). Here, we aimed to further these studies by examining alterations in the gut microbiome of juvenile Japanese macaques (Macaca fuscata) that were exposed to a maternal HFD, weaned onto a control diet, and later supplemented with a synbiotic comprised of psyllium seed and Enterococcus and Lactobacillus species. Eighteen month old offspring (n = 7) of 36% HFD fed dams were fed a control (14% fat) diet post weaning, then were synbiotic supplemented for 75 days and longitudinal stool and serum samples were obtained. All stool samples were subjected to 16S rRNA metagenomic sequencing, and microbiome profiles and serum lipids and triglycerides were compared to untreated, healthy age matched and diet matched controls (n = 7). Overall, 16S-based metagenomic analysis revealed that supplementation exerted minimal alterations to the gut microbiome including transient increased abundance of Lactobacillus species and decreased abundance of few bacterial genera, including Faecalibacterium and Anaerovibrio. However, serum lipid analysis revealed significant decreases in triglycerides, cholesterol, and LDL (p < 0.05). Nevertheless, supplemented juveniles challenged 4 months later were not protected from HFD-induced gut dysbiosis. Synbiotic supplementation is temporally associated with alterations in the gut microbiome and host lipid profiles of juvenile Japanese macaques that were previously exposed to a maternal HFD. Despite these presumptive temporal benefits, a protective effect against later HFD-challenge gut dysbiosis was not observed.

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The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 67 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 67 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 13%
Student > Ph. D. Student 8 12%
Student > Master 7 10%
Student > Bachelor 6 9%
Other 4 6%
Other 10 15%
Unknown 23 34%
Readers by discipline Count As %
Agricultural and Biological Sciences 12 18%
Medicine and Dentistry 8 12%
Biochemistry, Genetics and Molecular Biology 4 6%
Immunology and Microbiology 4 6%
Nursing and Health Professions 3 4%
Other 9 13%
Unknown 27 40%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 June 2023.
All research outputs
#3,511,417
of 25,048,615 outputs
Outputs from BMC Microbiology
#301
of 3,459 outputs
Outputs of similar age
#67,440
of 335,154 outputs
Outputs of similar age from BMC Microbiology
#5
of 30 outputs
Altmetric has tracked 25,048,615 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,459 research outputs from this source. They receive a mean Attention Score of 4.2. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 335,154 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 30 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.