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Mendeley readers
Attention Score in Context
| Title |
Cofilin activation in peripheral CD4 T cells of HIV-1 infected patients: a pilot study
|
|---|---|
| Published in |
Retrovirology, October 2008
|
| DOI | 10.1186/1742-4690-5-95 |
| Pubmed ID | |
| Authors |
Yuntao Wu, Alyson Yoder, Dongyang Yu, Weifeng Wang, Juan Liu, Tracey Barrett, David Wheeler, Karen Schlauch |
| Abstract |
Cofilin is an actin-depolymerizing factor that regulates actin dynamics critical for T cell migration and T cell activation. In unstimulated resting CD4 T cells, cofilin exists largely as a phosphorylated inactive form. Previously, we demonstrated that during HIV-1 infection of resting CD4 T cells, the viral envelope-CXCR4 signaling activates cofilin to overcome the static cortical actin restriction. In this pilot study, we have extended this in vitro observation and examined cofilin phosphorylation in resting CD4 T cells purified from the peripheral blood of HIV-1-infected patients. Here, we report that the resting T cells from infected patients carry significantly higher levels of active cofilin, suggesting that these resting cells have been primed in vivo in cofilin activity to facilitate HIV-1 infection. HIV-1-mediated aberrant activation of cofilin may also lead to abnormalities in T cell migration and activation that could contribute to viral pathogenesis. |
Mendeley readers
The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 2% |
| France | 1 | 2% |
| Unknown | 39 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 9 | 22% |
| Student > Ph. D. Student | 7 | 17% |
| Student > Doctoral Student | 4 | 10% |
| Professor | 4 | 10% |
| Student > Master | 4 | 10% |
| Other | 6 | 15% |
| Unknown | 7 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 10 | 24% |
| Agricultural and Biological Sciences | 7 | 17% |
| Medicine and Dentistry | 4 | 10% |
| Immunology and Microbiology | 4 | 10% |
| Psychology | 2 | 5% |
| Other | 5 | 12% |
| Unknown | 9 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 July 2018.
All research outputs
#8,534,528
of 25,373,627 outputs
Outputs from Retrovirology
#455
of 1,273 outputs
Outputs of similar age
#37,093
of 103,291 outputs
Outputs of similar age from Retrovirology
#7
of 11 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,273 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one has gotten more attention than average, scoring higher than 53% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 103,291 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.