Title |
Resistance to ursodeoxycholic acid-induced growth arrest can also result in resistance to deoxycholic acid-induced apoptosis and increased tumorgenicity
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Published in |
BMC Cancer, September 2006
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DOI | 10.1186/1471-2407-6-219 |
Pubmed ID | |
Authors |
Ashley A Powell, Sandeep Akare, Wenqing Qi, Pascal Herzer, Samira Jean-Louis, Rebecca A Feldman, Jesse D Martinez |
Abstract |
There is a large body of evidence which suggests that bile acids increase the risk of colon cancer and act as tumor promoters, however, the mechanism(s) of bile acids mediated tumorigenesis is not clear. Previously we showed that deoxycholic acid (DCA), a tumorogenic bile acid, and ursodeoxycholic acid (UDCA), a putative chemopreventive agent, exhibited distinct biological effects, yet appeared to act on some of the same signaling molecules. The present study was carried out to determine whether there is overlap in signaling pathways activated by tumorogenic bile acid DCA and chemopreventive bile acid UDCA. |
Mendeley readers
Geographical breakdown
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Portugal | 1 | 7% |
Unknown | 14 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 2 | 13% |
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Student > Doctoral Student | 1 | 7% |
Other | 3 | 20% |
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Unknown | 3 | 20% |