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ChIP'ing the mammalian genome: technical advances and insights into functional elements

Overview of attention for article published in Genome Medicine, September 2009
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2 patents

Citations

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51 Mendeley
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4 CiteULike
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Title
ChIP'ing the mammalian genome: technical advances and insights into functional elements
Published in
Genome Medicine, September 2009
DOI 10.1186/gm89
Pubmed ID
Authors

Eleanor Wong, Chia-Lin Wei

Abstract

Characterization of the functional components in mammalian genomes depends on our ability to completely elucidate the genetic and epigenetic regulatory networks of chromatin states and nuclear architecture. Such endeavors demand the availability of robust and effective approaches to characterizing protein-DNA associations in their native chromatin environments. Consider able progress has been made through the applica tion of chromatin immunoprecipitation (ChIP) to study chromatin biology in cells. Coupled with genome-wide analyses, ChIP-based assays enable us to take a global, unbiased and comprehensive view of transcriptional control, epigenetic regulation and chromatin structures, with high precision and versatility. The integrated knowledge derived from these studies is used to decipher gene regulatory networks and define genome organization. In this review, we discuss this powerful approach and its current advances. We also explore the possible future developments of ChIP-based approaches to interrogating long-range chromatin interactions and their impact on the mechanisms regulating gene expression.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 51 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 6%
United Kingdom 2 4%
Italy 2 4%
Unknown 44 86%

Demographic breakdown

Readers by professional status Count As %
Researcher 17 33%
Student > Ph. D. Student 9 18%
Student > Master 5 10%
Professor 4 8%
Professor > Associate Professor 4 8%
Other 9 18%
Unknown 3 6%
Readers by discipline Count As %
Agricultural and Biological Sciences 34 67%
Biochemistry, Genetics and Molecular Biology 4 8%
Medicine and Dentistry 4 8%
Immunology and Microbiology 1 2%
Neuroscience 1 2%
Other 2 4%
Unknown 5 10%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 November 2022.
All research outputs
#8,535,684
of 25,374,917 outputs
Outputs from Genome Medicine
#1,248
of 1,585 outputs
Outputs of similar age
#37,465
of 105,986 outputs
Outputs of similar age from Genome Medicine
#5
of 10 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,585 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 26.8. This one is in the 18th percentile – i.e., 18% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 105,986 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 19th percentile – i.e., 19% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 5 of them.