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P-gp activity is a critical resistance factor against AVE9633 and DM4 cytotoxicity in leukaemia cell lines, but not a major mechanism of chemoresistance in cells from acute myeloid leukaemia patients

Overview of attention for article published in BMC Cancer, June 2009
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Title
P-gp activity is a critical resistance factor against AVE9633 and DM4 cytotoxicity in leukaemia cell lines, but not a major mechanism of chemoresistance in cells from acute myeloid leukaemia patients
Published in
BMC Cancer, June 2009
DOI 10.1186/1471-2407-9-199
Pubmed ID
Authors

Ruoping Tang, Simy Cohen, Jean-Yves Perrot, Anne-Marie Faussat, Claudia Zuany-Amorim, Zora Marjanovic, Hamid Morjani, Fanny Fava, Elise Corre, Ollivier Legrand, Jean-Pierre Marie

Abstract

AVE9633 is a new immunoconjugate comprising a humanized monoclonal antibody, anti-CD33 antigen, linked through a disulfide bond to the maytansine derivative DM4, a cytotoxic agent and potent tubulin inhibitor. It is undergoing a phase I clinical trial. Chemoresistance to anti-mitotic agents has been shown to be related, in part, to overexpression of ABC proteins. The aim of the present study was to investigate the potential roles of P-gp, MRP1 and BCRP in cytotoxicity in AVE9633-induced acute myeloid leukaemia (AML).

Mendeley readers

The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 3%
United States 1 3%
Unknown 30 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 12 38%
Student > Ph. D. Student 6 19%
Professor 4 13%
Student > Postgraduate 2 6%
Student > Master 2 6%
Other 4 13%
Unknown 2 6%
Readers by discipline Count As %
Agricultural and Biological Sciences 11 34%
Pharmacology, Toxicology and Pharmaceutical Science 7 22%
Chemistry 4 13%
Medicine and Dentistry 2 6%
Biochemistry, Genetics and Molecular Biology 2 6%
Other 0 0%
Unknown 6 19%