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Direct interaction between the catalytic subunit of Protein Phosphatase 1 and pRb

Overview of attention for article published in Cancer Cell International, February 2006
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Title
Direct interaction between the catalytic subunit of Protein Phosphatase 1 and pRb
Published in
Cancer Cell International, February 2006
DOI 10.1186/1475-2867-6-3
Pubmed ID
Authors

Michele Vietri, Mariarita Bianchi, John W Ludlow, Sibylle Mittnacht, Emma Villa-Moruzzi

Abstract

The product of the retinoblastoma-susceptibility gene (pRb) is a substrate for Protein Phosphatase 1 (PP1). At mitotic exit, all three PP1 isoforms, alpha, gamma1 and delta, bind to pRb and dephosphorylate its Ser/Thr sites in a sequential and site-specific way. The pRb-C terminal has been reported to be necessary and sufficient for PP1alpha binding. The present study investigated whether the three PP1 isoforms from mitotic or asynchronous HeLa cells associate differentially with wild-type and pRb mutants, as well as the holoenzyme composition of the pRb-directed PP1.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 6%
Unknown 32 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 21%
Student > Bachelor 6 18%
Researcher 5 15%
Student > Doctoral Student 4 12%
Student > Master 3 9%
Other 1 3%
Unknown 8 24%
Readers by discipline Count As %
Agricultural and Biological Sciences 14 41%
Biochemistry, Genetics and Molecular Biology 8 24%
Computer Science 2 6%
Social Sciences 1 3%
Medicine and Dentistry 1 3%
Other 0 0%
Unknown 8 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 December 2016.
All research outputs
#7,454,951
of 22,790,780 outputs
Outputs from Cancer Cell International
#542
of 1,800 outputs
Outputs of similar age
#40,761
of 154,965 outputs
Outputs of similar age from Cancer Cell International
#2
of 3 outputs
Altmetric has tracked 22,790,780 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,800 research outputs from this source. They receive a mean Attention Score of 3.8. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 154,965 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one.