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Genome analysis of Clostridium perfringens isolates from healthy and necrotic enteritis infected chickens and turkeys

Overview of attention for article published in BMC Research Notes, July 2017
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Title
Genome analysis of Clostridium perfringens isolates from healthy and necrotic enteritis infected chickens and turkeys
Published in
BMC Research Notes, July 2017
DOI 10.1186/s13104-017-2594-9
Pubmed ID
Authors

Troels Ronco, Marc Stegger, Kim Lee Ng, Berit Lilje, Ulrike Lyhs, Paal Skytt Andersen, Karl Pedersen

Abstract

Clostridium perfringens causes gastrointestinal diseases in both humans and domestic animals. Type A strains expressing the NetB toxin are the main cause of necrotic enteritis (NE) in chickens, which has remarkable impact on animal welfare and production economy in the international poultry industry. Three pathogenicity loci NELoc-1, -2 and -3 and a collagen adhesion gene cnaA have been found to be associated with NE in chickens, whereas the presence of these has not been investigated in diseased turkeys. The purpose was to investigate the virulence associated genome content and the genetic relationship among 30 C. perfringens isolates from both healthy and NE infected chickens and turkeys, applying whole-genome sequencing. NELoc-1, -3, netB and cnaA were significantly associated with NE isolates from chickens, whereas only NELoc-2 was commonly observed in both diseased turkeys and chickens. A putative collagen adhesion gene that encodes a von Willebrand Factor (vWF) domain was identified in all diseased turkeys and designated as cnaD. The phylogenetic analysis based on single nucleotide polymorphisms showed that the isolates generally were not closely related. These results indicate that virulence factors and pathogenicity loci associated with NE in chickens are not important to the same extent in diseased turkeys except for NELoc-2. A putative collagen adhesion gene which potentially could be of importance in regard to the NE pathogenesis in turkeys was identified and need to be further investigated. Thus, the pathogenesis of NE in turkeys appears to be different from that of broiler chickens.

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Geographical breakdown

Country Count As %
Unknown 21 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 24%
Student > Bachelor 3 14%
Student > Ph. D. Student 2 10%
Other 2 10%
Student > Master 2 10%
Other 1 5%
Unknown 6 29%
Readers by discipline Count As %
Agricultural and Biological Sciences 10 48%
Veterinary Science and Veterinary Medicine 2 10%
Biochemistry, Genetics and Molecular Biology 1 5%
Economics, Econometrics and Finance 1 5%
Unknown 7 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 April 2018.
All research outputs
#20,480,611
of 23,041,514 outputs
Outputs from BMC Research Notes
#3,580
of 4,283 outputs
Outputs of similar age
#272,523
of 312,605 outputs
Outputs of similar age from BMC Research Notes
#120
of 142 outputs
Altmetric has tracked 23,041,514 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
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We're also able to compare this research output to 142 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.