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The solution structure of the prototype foamy virus RNase H domain indicates an important role of the basic loop in substrate binding

Overview of attention for article published in Retrovirology: Research & Treatment, September 2012
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (67th percentile)
  • Good Attention Score compared to outputs of the same age and source (75th percentile)

Mentioned by

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1 Wikipedia page

Citations

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8 Dimensions

Readers on

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13 Mendeley
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Title
The solution structure of the prototype foamy virus RNase H domain indicates an important role of the basic loop in substrate binding
Published in
Retrovirology: Research & Treatment, September 2012
DOI 10.1186/1742-4690-9-73
Pubmed ID
Authors

Berit Leo, Kristian Schweimer, Paul Rösch, Maximilian J Hartl, Birgitta M Wöhrl

Abstract

The ribonuclease H (RNase H) domains of retroviral reverse transcriptases play an essential role in the replication cycle of retroviruses. During reverse transcription of the viral genomic RNA, an RNA/DNA hybrid is created whose RNA strand needs to be hydrolyzed by the RNase H to enable synthesis of the second DNA strand by the DNA polymerase function of the reverse transcriptase. Here, we report the solution structure of the separately purified RNase H domain from prototype foamy virus (PFV) revealing the so-called C-helix and the adjacent basic loop, which both were suggested to be important in substrate binding and activity.

Mendeley readers

The data shown below were compiled from readership statistics for 13 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 13 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 38%
Other 1 8%
Student > Ph. D. Student 1 8%
Student > Bachelor 1 8%
Student > Master 1 8%
Other 1 8%
Unknown 3 23%
Readers by discipline Count As %
Agricultural and Biological Sciences 5 38%
Chemistry 2 15%
Biochemistry, Genetics and Molecular Biology 1 8%
Neuroscience 1 8%
Immunology and Microbiology 1 8%
Other 0 0%
Unknown 3 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 August 2014.
All research outputs
#969,612
of 4,156,414 outputs
Outputs from Retrovirology: Research & Treatment
#145
of 649 outputs
Outputs of similar age
#44,010
of 141,830 outputs
Outputs of similar age from Retrovirology: Research & Treatment
#7
of 28 outputs
Altmetric has tracked 4,156,414 research outputs across all sources so far. This one has received more attention than most of these and is in the 63rd percentile.
So far Altmetric has tracked 649 research outputs from this source. They receive a mean Attention Score of 3.6. This one has gotten more attention than average, scoring higher than 71% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 141,830 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.
We're also able to compare this research output to 28 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.