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Comparative profiling of the transcriptional response to iron restriction in six serotypes of Actinobacillus pleuropneumoniae with different virulence potential

Overview of attention for article published in BMC Genomics, December 2010
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1 Wikipedia page

Citations

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22 Dimensions

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43 Mendeley
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Title
Comparative profiling of the transcriptional response to iron restriction in six serotypes of Actinobacillus pleuropneumoniae with different virulence potential
Published in
BMC Genomics, December 2010
DOI 10.1186/1471-2164-11-698
Pubmed ID
Authors

Kirstine Klitgaard, Carsten Friis, Øystein Angen, Mette Boye

Abstract

Comparative analysis of gene expression among serotypes within a species can provide valuable information on important differences between related genomes. For the pig lung pathogen Actinobacillus pleuropneumoniae, 15 serotypes with a considerable variation in virulence potential and immunogenicity have been identified. This serotypic diversity can only partly be explained by amount of capsule and differences in the RTX toxin genes in their genomes. Iron acquisition in vivo is an important bacterial function and in pathogenic bacteria, iron-limitation is often a signal for the induction of virulence genes. We used a pan-genomic microarray to study the transcriptional response to iron restriction in vitro in six serotypes of A. pleuropneumoniae (1, 2, 3, 5b, 6, and 7), representing at least two levels of virulence.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
United States 1 2%
Brazil 1 2%
Unknown 40 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 26%
Researcher 7 16%
Student > Bachelor 7 16%
Student > Doctoral Student 3 7%
Student > Master 3 7%
Other 7 16%
Unknown 5 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 19 44%
Biochemistry, Genetics and Molecular Biology 8 19%
Environmental Science 2 5%
Medicine and Dentistry 2 5%
Business, Management and Accounting 1 2%
Other 4 9%
Unknown 7 16%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 April 2013.
All research outputs
#8,533,995
of 25,371,288 outputs
Outputs from BMC Genomics
#3,907
of 11,244 outputs
Outputs of similar age
#57,721
of 191,005 outputs
Outputs of similar age from BMC Genomics
#27
of 78 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 11,244 research outputs from this source. They receive a mean Attention Score of 4.8. This one has gotten more attention than average, scoring higher than 58% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 191,005 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 24th percentile – i.e., 24% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 78 others from the same source and published within six weeks on either side of this one. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.