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Genetic Enhancement of Behavioral Itch Responses in Mice Lacking Phosphoinositide 3-Kinase-γ (PI3Kγ)

Overview of attention for article published in Molecular Pain, January 2011
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1 Wikipedia page

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19 Mendeley
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Title
Genetic Enhancement of Behavioral Itch Responses in Mice Lacking Phosphoinositide 3-Kinase-γ (PI3Kγ)
Published in
Molecular Pain, January 2011
DOI 10.1186/1744-8069-7-96
Pubmed ID
Authors

Bolam Lee, Giannina Descalzi, Jinhee Baek, Jae-Ick Kim, Hye-Ryeon Lee, Kyungmin Lee, Bong-Kiun Kaang, Min Zhuo

Abstract

Phosphoinositide 3-kinases (PI3Ks) are important for synaptic plasticity and various brain functions. The only class IB isoform of PI3K, PI3Kγ, has received the most attention due to its unique roles in synaptic plasticity and cognition. However, the potential role of PI3Kγ in sensory transmission, such as pain and itch has not been examined. In this study, we present the evidence for the first time, that genetic deletion of PI3Kγ enhanced scratching behaviours in histamine-dependent and protease-activated receptor 2 (PAR-2)-dependent itch. In contrast, PI3Kγ-deficient mice did not exhibit enhanced scratching in chloroquine-induced itch, suggesting that PI3Kγ selectively contributes to certain types of behavioal itch response. Furthermore, PI3Kγ-deficient mice exhibited normal acute nociceptive responses to thermal and mechanical noxious stimuli. Behavioral licking responses to intraplantar injections of formalin and mechanical allodynia in a chronic inflammatory pain model (CFA) were also not affected by PI3Kγ gene deletion. Our findings indicate that PI3Kγ selectively contributes to behavioral itching induced by histamine and PAR-2 agonist, but not chloroquine agonist.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 19 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 21%
Student > Ph. D. Student 4 21%
Student > Doctoral Student 2 11%
Student > Bachelor 2 11%
Other 1 5%
Other 3 16%
Unknown 3 16%
Readers by discipline Count As %
Medicine and Dentistry 4 21%
Agricultural and Biological Sciences 4 21%
Biochemistry, Genetics and Molecular Biology 3 16%
Neuroscience 3 16%
Physics and Astronomy 1 5%
Other 1 5%
Unknown 3 16%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 September 2021.
All research outputs
#8,535,472
of 25,374,917 outputs
Outputs from Molecular Pain
#190
of 669 outputs
Outputs of similar age
#57,799
of 190,479 outputs
Outputs of similar age from Molecular Pain
#12
of 36 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 669 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one has gotten more attention than average, scoring higher than 61% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 190,479 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 36 others from the same source and published within six weeks on either side of this one. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.