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SQUID: transcriptomic structural variation detection from RNA-seq

Overview of attention for article published in Genome Biology, April 2018
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (86th percentile)
  • Average Attention Score compared to outputs of the same age and source

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29 X users

Citations

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132 Mendeley
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2 CiteULike
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Title
SQUID: transcriptomic structural variation detection from RNA-seq
Published in
Genome Biology, April 2018
DOI 10.1186/s13059-018-1421-5
Pubmed ID
Authors

Cong Ma, Mingfu Shao, Carl Kingsford

Abstract

Transcripts are frequently modified by structural variations, which lead to fused transcripts of either multiple genes, known as a fusion gene, or a gene and a previously non-transcribed sequence. Detecting these modifications, called transcriptomic structural variations (TSVs), especially in cancer tumor sequencing, is an important and challenging computational problem. We introduce SQUID, a novel algorithm to predict both fusion-gene and non-fusion-gene TSVs accurately from RNA-seq alignments. SQUID unifies both concordant and discordant read alignments into one model and doubles the precision on simulation data compared to other approaches. Using SQUID, we identify novel non-fusion-gene TSVs on TCGA samples.

X Demographics

X Demographics

The data shown below were collected from the profiles of 29 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 132 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 132 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 31 23%
Student > Ph. D. Student 25 19%
Student > Master 12 9%
Other 10 8%
Student > Bachelor 8 6%
Other 21 16%
Unknown 25 19%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 43 33%
Agricultural and Biological Sciences 36 27%
Computer Science 9 7%
Medicine and Dentistry 5 4%
Engineering 4 3%
Other 7 5%
Unknown 28 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 February 2019.
All research outputs
#2,283,174
of 25,382,440 outputs
Outputs from Genome Biology
#1,882
of 4,468 outputs
Outputs of similar age
#47,548
of 343,384 outputs
Outputs of similar age from Genome Biology
#19
of 35 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,468 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.6. This one has gotten more attention than average, scoring higher than 57% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 343,384 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 35 others from the same source and published within six weeks on either side of this one. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.