Title |
Identification of genes for small non-coding RNAs that belong to the regulon of the two-component regulatory system CiaRH in Streptococcus
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Published in |
BMC Genomics, November 2010
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DOI | 10.1186/1471-2164-11-661 |
Pubmed ID | |
Authors |
Patrick Marx, Michael Nuhn, Martá Kovács, Regine Hakenbeck, Reinhold Brückner |
Abstract |
Post-transcriptional regulation by small RNAs (sRNAs) in bacteria is now recognized as a wide-spread regulatory mechanism modulating a variety of physiological responses including virulence. In Streptococcus pneumoniae, an important human pathogen, the first sRNAs to be described were found in the regulon of the CiaRH two-component regulatory system. Five of these sRNAs were detected and designated csRNAs for cia-dependent small RNAs. CiaRH pleiotropically affects β-lactam resistance, autolysis, virulence, and competence development by yet to be defined molecular mechanisms. Since CiaRH is highly conserved among streptococci, it is of interest to determine if csRNAs are also included in the CiaRH regulon in this group of organisms consisting of commensal as well as pathogenic species. Knowledge on the participation of csRNAs in CiaRH-dependent regulatory events will be the key to define the physiological role of this important control system. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 40 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 13 | 33% |
Researcher | 5 | 13% |
Professor > Associate Professor | 4 | 10% |
Student > Bachelor | 3 | 8% |
Professor | 2 | 5% |
Other | 6 | 15% |
Unknown | 7 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 18 | 45% |
Biochemistry, Genetics and Molecular Biology | 6 | 15% |
Immunology and Microbiology | 5 | 13% |
Veterinary Science and Veterinary Medicine | 1 | 3% |
Arts and Humanities | 1 | 3% |
Other | 1 | 3% |
Unknown | 8 | 20% |