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A comparative genomics study of carbohydrate/glucose metabolic genes: from fish to mammals

Overview of attention for article published in BMC Genomics, April 2018
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Title
A comparative genomics study of carbohydrate/glucose metabolic genes: from fish to mammals
Published in
BMC Genomics, April 2018
DOI 10.1186/s12864-018-4647-4
Pubmed ID
Authors

Yuru Zhang, Chaobin Qin, Liping Yang, Ronghua Lu, Xiaoyan Zhao, Guoxing Nie

Abstract

Glucose plays a key role as an energy source in most mammals, but its importance in fish appears to be limited that so far seemed to belong to diabetic humans only. Several laboratories worldwide have made important efforts in order to better understand this strange phenotype observed in fish. However, the mechanism of carbohydrate/glucose metabolism is astonishingly complex. Why basal glycaemia is different between fish and mammals and how carbohydrate metabolism is different amongst organisms is largely uncharted territory. The utilization of comparative systems biology with model vertebrates to explore fish metabolism has become an essential approach to unravelling hidden in vivo mechanisms. In this study, we first built a database containing 791, 593, 523, 666 and 698 carbohydrate/glucose metabolic genes from the genomes of Danio rerio, Xenopus tropicalis, Gallus gallus, Mus musculus and Homo sapiens, respectively, and most of these genes in our database are predicted to encode specific enzymes that play roles in defined reactions; over 57% of these genes are related to human type 2 diabetes. Then, we systematically compared these genes and found that more than 70% of the carbohydrate/glucose metabolic genes are conserved in the five species. Interestingly, there are 4 zebrafish-specific genes (si:ch211-167b20.8, CABZ01043017.1, socs9 and eif4e1c) and 1 human-specific gene (CALML6) that may alter glucose utilization in their corresponding species. Interestingly, these 5 genes are all carbohydrate regulation factors, but the enzymes themselves are involved in insulin regulation pathways. Lastly, in order to facilitate the use of our data sets, we constructed a glucose metabolism database platform ( http://101.200.43.1:10000/ ). This study provides the first systematic genomic insights into carbohydrate/glucose metabolism. After exhaustive analysis, we found that most metabolic genes are conserved in vertebrates. This work may resolve some of the complexities of carbohydrate/glucose metabolic heterogeneity amongst different vertebrates and may provide a reference for the treatment of diabetes and for applications in the aquaculture industry.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 72 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 72 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 15 21%
Student > Ph. D. Student 11 15%
Student > Bachelor 7 10%
Student > Master 4 6%
Unspecified 3 4%
Other 11 15%
Unknown 21 29%
Readers by discipline Count As %
Agricultural and Biological Sciences 17 24%
Biochemistry, Genetics and Molecular Biology 13 18%
Medicine and Dentistry 4 6%
Unspecified 3 4%
Veterinary Science and Veterinary Medicine 2 3%
Other 9 13%
Unknown 24 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 April 2018.
All research outputs
#20,481,952
of 23,043,346 outputs
Outputs from BMC Genomics
#9,325
of 10,697 outputs
Outputs of similar age
#290,344
of 329,173 outputs
Outputs of similar age from BMC Genomics
#197
of 223 outputs
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