Efficient production of l-lactic acid by an engineered Thermoanaerobacterium aotearoense with broad substrate specificity.
Biotechnology for Biofuels, August 2013
Xiaofeng Yang, Zhicheng Lai, Chaofeng Lai, Muzi Zhu, Shuang Li, Jufang Wang, Xiaoning Wang
Efficient conversion of lignocellulosic biomass to optically pure lactic acid is a key challenge for the economical production of biodegradable poly-lactic acid. A recently isolated strain, Thermoanaerobacterium aotearoense SCUT27, is promising as an efficient lactic acid production bacterium from biomass due to its broad substrate specificity. Additionally, its strictly anaerobic and thermophilic characteristics suppress contamination from other microoragnisms. Herein, we report the significant improvements of concentration and yield in lactic acid production from various lignocellulosic derived sugars, achieved by the carbon flux redirection through homologous recombination in T. aotearoense SCUT27.
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