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Disruption of CTCF at the miR-125b1 locus in gynecological cancers

Overview of attention for article published in BMC Cancer, January 2012
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (80th percentile)
  • High Attention Score compared to outputs of the same age and source (83rd percentile)

Mentioned by

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1 patent
wikipedia
1 Wikipedia page

Citations

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32 Dimensions

Readers on

mendeley
52 Mendeley
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Title
Disruption of CTCF at the miR-125b1 locus in gynecological cancers
Published in
BMC Cancer, January 2012
DOI 10.1186/1471-2407-12-40
Pubmed ID
Authors

Ernesto Soto-Reyes, Rodrigo González-Barrios, Fernanda Cisneros-Soberanis, Roberto Herrera-Goepfert, Víctor Pérez, David Cantú, Diddier Prada, Clementina Castro, Félix Recillas-Targa, Luis A Herrera

Abstract

In cancer cells, transcriptional gene silencing has been associated with genetic and epigenetic defects. The disruption of DNA methylation patterns and covalent histone marks has been associated with cancer development. Until recently, microRNA (miRNA) gene silencing was not well understood. In particular, miR-125b1 has been suggested to be an miRNA with tumor suppressor activity, and it has been shown to be deregulated in various human cancers. In the present study, we evaluated the DNA methylation at the CpG island proximal to the transcription start site of miR-125b1 in cancer cell lines as well as in normal tissues and gynecological tumor samples. In addition, we analyzed the association of CTCF and covalent histone modifications at the miR-125b1 locus.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Mexico 2 4%
India 1 2%
United States 1 2%
Unknown 48 92%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 16 31%
Student > Ph. D. Student 9 17%
Researcher 6 12%
Student > Postgraduate 4 8%
Student > Master 4 8%
Other 5 10%
Unknown 8 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 16 31%
Biochemistry, Genetics and Molecular Biology 15 29%
Medicine and Dentistry 8 15%
Immunology and Microbiology 2 4%
Earth and Planetary Sciences 1 2%
Other 1 2%
Unknown 9 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 March 2018.
All research outputs
#4,697,128
of 22,792,160 outputs
Outputs from BMC Cancer
#1,204
of 8,294 outputs
Outputs of similar age
#41,743
of 246,583 outputs
Outputs of similar age from BMC Cancer
#10
of 71 outputs
Altmetric has tracked 22,792,160 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 8,294 research outputs from this source. They receive a mean Attention Score of 4.3. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 246,583 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 71 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.