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The retinoblastoma family of proteins and their regulatory functions in the mammalian cell division cycle

Overview of attention for article published in Cell Division, January 2012
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#9 of 111)
  • High Attention Score compared to outputs of the same age (83rd percentile)

Mentioned by

patent
2 patents
wikipedia
2 Wikipedia pages

Citations

dimensions_citation
182 Dimensions

Readers on

mendeley
284 Mendeley
citeulike
1 CiteULike
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Title
The retinoblastoma family of proteins and their regulatory functions in the mammalian cell division cycle
Published in
Cell Division, January 2012
DOI 10.1186/1747-1028-7-10
Pubmed ID
Authors

Shauna A Henley, Frederick A Dick

Abstract

The retinoblastoma (RB) family of proteins are found in organisms as distantly related as humans, plants, and insects. These proteins play a key role in regulating advancement of the cell division cycle from the G1 to S-phases. This is achieved through negative regulation of two important positive regulators of cell cycle entry, E2F transcription factors and cyclin dependent kinases. In growth arrested cells transcriptional activity by E2Fs is repressed by RB proteins. Stimulation of cell cycle entry by growth factor signaling leads to activation of cyclin dependent kinases. They in turn phosphorylate and inactivate the RB family proteins, leading to E2F activation and additional cyclin dependent kinase activity. This propels the cell cycle irreversibly forward leading to DNA synthesis. This review will focus on the basic biochemistry and cell biology governing the regulation and activity of mammalian RB family proteins in cell cycle control.

Mendeley readers

The data shown below were compiled from readership statistics for 284 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 <1%
Italy 1 <1%
Egypt 1 <1%
Romania 1 <1%
Spain 1 <1%
United States 1 <1%
Serbia 1 <1%
Unknown 276 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 74 26%
Student > Bachelor 43 15%
Researcher 38 13%
Student > Master 38 13%
Other 16 6%
Other 50 18%
Unknown 25 9%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 100 35%
Agricultural and Biological Sciences 95 33%
Medicine and Dentistry 31 11%
Pharmacology, Toxicology and Pharmaceutical Science 6 2%
Chemistry 6 2%
Other 18 6%
Unknown 28 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 September 2020.
All research outputs
#2,631,931
of 18,783,186 outputs
Outputs from Cell Division
#9
of 111 outputs
Outputs of similar age
#37,501
of 228,272 outputs
Outputs of similar age from Cell Division
#1
of 1 outputs
Altmetric has tracked 18,783,186 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 111 research outputs from this source. They receive a mean Attention Score of 2.7. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 228,272 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them