You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
Mendeley readers
Attention Score in Context
| Title |
The retinoblastoma family of proteins and their regulatory functions in the mammalian cell division cycle
|
|---|---|
| Published in |
Cell Division, March 2012
|
| DOI | 10.1186/1747-1028-7-10 |
| Pubmed ID | |
| Authors |
Shauna A Henley, Frederick A Dick |
| Abstract |
The retinoblastoma (RB) family of proteins are found in organisms as distantly related as humans, plants, and insects. These proteins play a key role in regulating advancement of the cell division cycle from the G1 to S-phases. This is achieved through negative regulation of two important positive regulators of cell cycle entry, E2F transcription factors and cyclin dependent kinases. In growth arrested cells transcriptional activity by E2Fs is repressed by RB proteins. Stimulation of cell cycle entry by growth factor signaling leads to activation of cyclin dependent kinases. They in turn phosphorylate and inactivate the RB family proteins, leading to E2F activation and additional cyclin dependent kinase activity. This propels the cell cycle irreversibly forward leading to DNA synthesis. This review will focus on the basic biochemistry and cell biology governing the regulation and activity of mammalian RB family proteins in cell cycle control. |
Mendeley readers
The data shown below were compiled from readership statistics for 332 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | <1% |
| Italy | 1 | <1% |
| Egypt | 1 | <1% |
| Romania | 1 | <1% |
| Spain | 1 | <1% |
| United States | 1 | <1% |
| Serbia | 1 | <1% |
| Unknown | 324 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 80 | 24% |
| Student > Bachelor | 47 | 14% |
| Researcher | 40 | 12% |
| Student > Master | 40 | 12% |
| Other | 16 | 5% |
| Other | 50 | 15% |
| Unknown | 59 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 105 | 32% |
| Agricultural and Biological Sciences | 96 | 29% |
| Medicine and Dentistry | 34 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 2% |
| Chemistry | 6 | 2% |
| Other | 21 | 6% |
| Unknown | 63 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 November 2023.
All research outputs
#3,798,287
of 25,371,288 outputs
Outputs from Cell Division
#9
of 160 outputs
Outputs of similar age
#23,181
of 168,987 outputs
Outputs of similar age from Cell Division
#1
of 6 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 160 research outputs from this source. They receive a mean Attention Score of 2.6. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 168,987 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them