Report for: The retinoblastoma family of proteins and their regulatory functions in the mammalian cell division cycle

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Title	The retinoblastoma family of proteins and their regulatory functions in the mammalian cell division cycle
Published in	Cell Division, January 2012
DOI	10.1186/1747-1028-7-10
Pubmed ID	22417103
Authors	Shauna A Henley, Frederick A Dick
Abstract	The retinoblastoma (RB) family of proteins are found in organisms as distantly related as humans, plants, and insects. These proteins play a key role in regulating advancement of the cell division cycle from the G1 to S-phases. This is achieved through negative regulation of two important positive regulators of cell cycle entry, E2F transcription factors and cyclin dependent kinases. In growth arrested cells transcriptional activity by E2Fs is repressed by RB proteins. Stimulation of cell cycle entry by growth factor signaling leads to activation of cyclin dependent kinases. They in turn phosphorylate and inactivate the RB family proteins, leading to E2F activation and additional cyclin dependent kinase activity. This propels the cell cycle irreversibly forward leading to DNA synthesis. This review will focus on the basic biochemistry and cell biology governing the regulation and activity of mammalian RB family proteins in cell cycle control.

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Mendeley readers

The data shown below were compiled from readership statistics for 305 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country	Count	As %
United Kingdom	2	<1%
Italy	1	<1%
Egypt	1	<1%
Romania	1	<1%
Spain	1	<1%
United States	1	<1%
Serbia	1	<1%
Unknown	297	97%

Demographic breakdown

Readers by professional status	Count	As %
Student > Ph. D. Student	77	25%
Student > Bachelor	44	14%
Researcher	40	13%
Student > Master	38	12%
Other	16	5%
Other	52	17%
Unknown	38	12%

Readers by discipline	Count	As %
Biochemistry, Genetics and Molecular Biology	101	33%
Agricultural and Biological Sciences	97	32%
Medicine and Dentistry	34	11%
Pharmacology, Toxicology and Pharmaceutical Science	7	2%
Chemistry	6	2%
Other	19	6%
Unknown	41	13%

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 September 2020.

All research outputs

#3,272,848

of 22,792,160 outputs

Outputs from Cell Division

#10

of 131 outputs

Outputs of similar age

#27,108

of 244,407 outputs

Outputs of similar age from Cell Division

of 7 outputs

Altmetric has tracked 22,792,160 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.

So far Altmetric has tracked 131 research outputs from this source. They receive a mean Attention Score of 3.1. This one has done particularly well, scoring higher than 91% of its peers.

Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 244,407 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.

We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them

The retinoblastoma family of proteins and their regulatory functions in the mammalian cell division cycle

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Attention Score in Context