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NCX-DB: a unified resource for integrative analysis of the sodium calcium exchanger super-family

Overview of attention for article published in BMC Neuroscience, April 2018
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Title
NCX-DB: a unified resource for integrative analysis of the sodium calcium exchanger super-family
Published in
BMC Neuroscience, April 2018
DOI 10.1186/s12868-018-0423-2
Pubmed ID
Authors

Katrin Bode, Damien M. O’Halloran

Abstract

Na+/Ca2+ exchangers are low-affinity high-capacity transporters that mediate Ca2+ extrusion by coupling Ca2+ efflux to the influx of Na+ ions. The Na+/Ca2+ exchangers form a super-family comprised of three branches each differing in ion-substrate selectivity: Na+/Ca2+ exchangers (NCX), Na+/Ca2+/K+ exchangers, and Ca2+/cation exchangers. Their primary function is to maintain Ca2+ homeostasis and play a particularly important role in excitable cells that experience transient Ca2+ fluxes. Research into the role and activity of Na+/Ca2+ exchangers has focused extensively on the cardio-vascular system, however, growing evidence suggests that Na+/Ca2+ exchangers play a key role in neuronal processes such as memory formation, learning, oligodendrocyte differentiation, neuroprotection during brain ischemia and axon guidance. They have also been implicated in pathologies such as Alzheimer's disease, Parkinson's disease, Multiple Sclerosis and Epilepsy, however, a clear understanding of their mechanism during disease is lacking. To date, there has never been a central resource or database for Na+/Ca2+ exchangers. With clear disease relevance and ever-increasing research on Na+/Ca2+ exchangers from both model and non-model species, a database that unifies the data on Na+/Ca2+ exchangers is needed for future research. NCX-DB is a publicly available database with a web interface that enables users to explore various Na+/Ca2+ exchangers, perform cross-species sequence comparison, identify new exchangers, and stay-up to date with recent literature. NCX-DB is available on the web via an interactive user interface with an intuitive design, which is applicable for the identification and comparison of Na+/Ca2+ exchanger proteins across diverse species.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 39 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 23%
Student > Bachelor 7 18%
Student > Master 5 13%
Other 2 5%
Researcher 2 5%
Other 4 10%
Unknown 10 26%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 9 23%
Neuroscience 6 15%
Medicine and Dentistry 6 15%
Psychology 3 8%
Agricultural and Biological Sciences 2 5%
Other 1 3%
Unknown 12 31%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 March 2021.
All research outputs
#17,945,904
of 23,043,346 outputs
Outputs from BMC Neuroscience
#821
of 1,252 outputs
Outputs of similar age
#238,050
of 327,991 outputs
Outputs of similar age from BMC Neuroscience
#16
of 26 outputs
Altmetric has tracked 23,043,346 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,252 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 29th percentile – i.e., 29% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 327,991 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 22nd percentile – i.e., 22% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 26 others from the same source and published within six weeks on either side of this one. This one is in the 34th percentile – i.e., 34% of its contemporaries scored the same or lower than it.