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The 4-aminopiperidine series has limited anti-tubercular and anti-staphylococcus aureus activity

Overview of attention for article published in Journal of Negative Results in BioMedicine, February 2015
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Mentioned by

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2 tweeters

Citations

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2 Dimensions

Readers on

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21 Mendeley
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Title
The 4-aminopiperidine series has limited anti-tubercular and anti-staphylococcus aureus activity
Published in
Journal of Negative Results in BioMedicine, February 2015
DOI 10.1186/s12952-015-0024-x
Pubmed ID
Authors

N Susantha Chandrasekera, Torey Alling, Mai Bailey, Aaron Korkegian, James Ahn, Yulia Ovechkina, Joshua Odingo, Tanya Parish

Abstract

Tuberculosis (TB) caused by Mycobacterium tuberculosis is the leading cause of death from a bacterial infection. The 4-aminopiperidine (PIP) series has been reported as having anti-bacterial activity against M. tuberculosis. We explored this series for its potential to inhibit aerobic growth of M. tuberculosis. We examined substitution at the N-1 position and C-4 position of the piperidine and modifications of the piperidine moiety systematically to delineate structure-activity relationships influencing potency. Compounds were tested for growth-inhibitory activity against virulent M. tuberculosis. A selected set of compounds were also tested for its activity against Staphylococcus aureus. The compound with a norbornenylmethyl substituent at the N-1 position and N-benzyl-N-phenethylamine at the C-4 position of the piperidine (1) was the only active compound with a minimum inhibitory concentration (MIC) of 10 μM against M. tuberculosis. Compounds were not active against S. aureus. We were unable to derive any other analogs with MIC < 20 μM against M. tuberculosis. Therefore we conclude that the lack of activity is a liability in this series precluding it from further development.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 21 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 19%
Student > Postgraduate 3 14%
Student > Bachelor 3 14%
Student > Master 2 10%
Student > Ph. D. Student 1 5%
Other 3 14%
Unknown 5 24%
Readers by discipline Count As %
Medicine and Dentistry 7 33%
Immunology and Microbiology 3 14%
Biochemistry, Genetics and Molecular Biology 2 10%
Arts and Humanities 1 5%
Environmental Science 1 5%
Other 1 5%
Unknown 6 29%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 March 2015.
All research outputs
#2,397,925
of 4,833,230 outputs
Outputs from Journal of Negative Results in BioMedicine
#54
of 98 outputs
Outputs of similar age
#77,578
of 154,873 outputs
Outputs of similar age from Journal of Negative Results in BioMedicine
#3
of 7 outputs
Altmetric has tracked 4,833,230 research outputs across all sources so far. This one is in the 47th percentile – i.e., 47% of other outputs scored the same or lower than it.
So far Altmetric has tracked 98 research outputs from this source. They receive a mean Attention Score of 4.6. This one is in the 37th percentile – i.e., 37% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 154,873 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.