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Distinct increased outliers among 136 rectal cancer patients assessed by γH2AX

Overview of attention for article published in Radiation Oncology, February 2015
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Title
Distinct increased outliers among 136 rectal cancer patients assessed by γH2AX
Published in
Radiation Oncology, February 2015
DOI 10.1186/s13014-015-0344-5
Pubmed ID
Authors

Jana Kroeber, Barbara Wenger, Manuela Schwegler, Christoph Daniel, Manfred Schmidt, Cholpon S Djuzenova, Bülent Polat, Michael Flentje, Rainer Fietkau, Luitpold V Distel

Abstract

In recent years attention has focused on γH2AX as a very sensitive double strand break indicator. It has been suggested that γH2AX might be able to predict individual radiosensitivity. Our aim was to study the induction and repair of DNA double strand breaks labelled by γH2AX in a large cohort. In a prospective study lymphocytes of 136 rectal cancer (RC) patients and 59 healthy individuals were ex vivo irradiated (IR) and initial DNA damage was compared to remaining DNA damage after 2 Gy and 24 hours repair time and preexisting DNA damage in unirradiated lymphocytes. Lymphocytes were immunostained with anti-γH2AX antibodies and microscopic images with an extended depth of field were acquired. γH2AX foci counting was performed using a semi-automatic image analysis software. Distinct increased values of preexisting and remaining γH2AX foci in the group of RC patients were found compared to the healthy individuals. Additionally there are clear differences within the groups and there are outliers in about 12% of the RC patients after ex vivo IR. The γH2AX assay has the capability to identify a group of outliers which are most probably patients with increased radiosensitivity having the highest risk of suffering radiotherapy-related late sequelae.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 17 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 4 24%
Other 3 18%
Student > Ph. D. Student 2 12%
Professor > Associate Professor 2 12%
Student > Doctoral Student 1 6%
Other 4 24%
Unknown 1 6%
Readers by discipline Count As %
Medicine and Dentistry 9 53%
Biochemistry, Genetics and Molecular Biology 4 24%
Social Sciences 1 6%
Sports and Recreations 1 6%
Unknown 2 12%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 February 2015.
All research outputs
#13,429,013
of 22,792,160 outputs
Outputs from Radiation Oncology
#651
of 2,054 outputs
Outputs of similar age
#176,521
of 357,812 outputs
Outputs of similar age from Radiation Oncology
#33
of 65 outputs
Altmetric has tracked 22,792,160 research outputs across all sources so far. This one is in the 39th percentile – i.e., 39% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,054 research outputs from this source. They receive a mean Attention Score of 2.7. This one has gotten more attention than average, scoring higher than 64% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 357,812 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 49th percentile – i.e., 49% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 65 others from the same source and published within six weeks on either side of this one. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.