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CCAAT/enhancer-binding protein β promotes receptor activator of nuclear factor-kappa-B ligand (RANKL) expression and osteoclast formation in the synovium in rheumatoid arthritis

Overview of attention for article published in Arthritis Research & Therapy, January 2015
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Title
CCAAT/enhancer-binding protein β promotes receptor activator of nuclear factor-kappa-B ligand (RANKL) expression and osteoclast formation in the synovium in rheumatoid arthritis
Published in
Arthritis Research & Therapy, January 2015
DOI 10.1186/s13075-015-0532-6
Pubmed ID
Authors

Hidetoshi Tsushima, Ken Okazaki, Kohei Ishihara, Takahiro Ushijima, Yukihide Iwamoto

Abstract

CCAAT/enhancer-binding protein β (C/EBPβ) is a transcription factor that is activated in the synovium in rheumatoid arthritis (RA) and promotes expression of various matrix metalloproteinases. In this study, we examined whether C/EBPβ mediates the expression of receptor activator of nuclear factor-kappa-B ligand (RANKL) and drives osteoclast formation in primary fibroblast-like synoviocytes (FLS) from RA patients. The cooperation of C/EBPβ and activation transcription factor-4 (ATF4) in the regulation of the RANKL promoter was also investigated.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 3%
France 1 3%
Unknown 29 94%

Demographic breakdown

Readers by professional status Count As %
Student > Master 8 26%
Student > Bachelor 4 13%
Student > Ph. D. Student 4 13%
Other 2 6%
Researcher 2 6%
Other 4 13%
Unknown 7 23%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 7 23%
Medicine and Dentistry 7 23%
Agricultural and Biological Sciences 6 19%
Arts and Humanities 1 3%
Pharmacology, Toxicology and Pharmaceutical Science 1 3%
Other 2 6%
Unknown 7 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 March 2015.
All research outputs
#20,262,276
of 22,792,160 outputs
Outputs from Arthritis Research & Therapy
#2,744
of 2,976 outputs
Outputs of similar age
#295,727
of 353,005 outputs
Outputs of similar age from Arthritis Research & Therapy
#53
of 56 outputs
Altmetric has tracked 22,792,160 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,976 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.9. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 353,005 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 56 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.