Title |
Selection of organisms for the co-evolution-based study of protein interactions
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Published in |
BMC Bioinformatics, September 2011
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DOI | 10.1186/1471-2105-12-363 |
Pubmed ID | |
Authors |
Dorota Herman, David Ochoa, David Juan, Daniel Lopez, Alfonso Valencia, Florencio Pazos |
Abstract |
The prediction and study of protein interactions and functional relationships based on similarity of phylogenetic trees, exemplified by the mirrortree and related methodologies, is being widely used. Although dependence between the performance of these methods and the set of organisms used to build the trees was suspected, so far nobody assessed it in an exhaustive way, and, in general, previous works used as many organisms as possible. In this work we asses the effect of using different sets of organism (chosen according with various phylogenetic criteria) on the performance of this methodology in detecting protein interactions of different nature. |
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United Kingdom | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
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Members of the public | 1 | 50% |
Scientists | 1 | 50% |
Mendeley readers
Geographical breakdown
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United States | 4 | 6% |
Spain | 4 | 6% |
Germany | 1 | 1% |
Italy | 1 | 1% |
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Netherlands | 1 | 1% |
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Researcher | 24 | 33% |
Student > Ph. D. Student | 15 | 21% |
Other | 6 | 8% |
Student > Bachelor | 5 | 7% |
Student > Master | 5 | 7% |
Other | 13 | 18% |
Unknown | 4 | 6% |
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Mathematics | 1 | 1% |
Environmental Science | 1 | 1% |
Other | 2 | 3% |
Unknown | 4 | 6% |