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Early risk factors for adult bipolar disorder in adolescents with mood disorders: a 15-year follow-up of a community sample

Overview of attention for article published in BMC Psychiatry, December 2014
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Title
Early risk factors for adult bipolar disorder in adolescents with mood disorders: a 15-year follow-up of a community sample
Published in
BMC Psychiatry, December 2014
DOI 10.1186/s12888-014-0363-z
Pubmed ID
Authors

Aivar Päären, Hannes Bohman, Lars von Knorring, Gunilla Olsson, Anne-Liis von Knorring, Ulf Jonsson

Abstract

BackgroundWe aimed to outline the early risk factors for adult bipolar disorder (BPD) in adolescents with mood disorders.MethodsAdolescents (16¿17 years old) with mood disorders (n¿=¿287; 90 participants with hypomania spectrum episodes and 197 with major depressive disorder [MDD]) were identified from a community sample. Fifteen years later (at 30¿33 years of age), mood episodes were assessed (n¿=¿194). The risk of developing BPD (n¿=¿22), compared with MDD (n¿=¿104) or no mood episodes in adulthood (n¿=¿68), was estimated via logistic regression. Adolescent mood symptoms, non-mood disorders, and family characteristics were assessed as potential risk factors.ResultsAmong the adolescents with mood disorders, a family history of BPD was the strongest predictor of developing BPD compared with having no mood episodes in adulthood (OR¿=¿5.94; 95% CI¿=¿1.11-31.73), whereas disruptive disorders significantly increased the risk of developing BPD compared with developing MDD (OR¿=¿2.94; CI¿=¿1.06-8.12). The risk that adolescents with MDD would develop adult BPD, versus having no mood episodes in adulthood, was elevated among those with an early disruptive disorder (OR¿=¿3.62; CI¿=¿1.09-12.07) or multiple somatic symptoms (OR¿=¿6.60; CI¿=¿1.70-25.67). Only disruptive disorders significantly predicted adult BPD among adolescents with MDD versus continued MDD in adulthood (OR¿=¿3.59; CI¿=¿1.17-10.97). Only a few adolescents with hypomania spectrum episodes continued to have BPD as adults, and anxiety disorders appeared to increase this risk.ConclusionsAlthough most of the identified potential risk factors are likely general predictors of continued mood disorders, disruptive disorders emerged as specific predictors of developing adult BPD among adolescents with MDD.

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Mendeley readers

The data shown below were compiled from readership statistics for 70 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 70 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 13 19%
Student > Bachelor 10 14%
Student > Ph. D. Student 9 13%
Researcher 8 11%
Student > Postgraduate 4 6%
Other 13 19%
Unknown 13 19%
Readers by discipline Count As %
Psychology 20 29%
Medicine and Dentistry 20 29%
Neuroscience 4 6%
Social Sciences 3 4%
Nursing and Health Professions 2 3%
Other 5 7%
Unknown 16 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 October 2015.
All research outputs
#14,631,135
of 18,998,919 outputs
Outputs from BMC Psychiatry
#3,031
of 3,976 outputs
Outputs of similar age
#148,719
of 225,454 outputs
Outputs of similar age from BMC Psychiatry
#1
of 1 outputs
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