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Amoxillin- and pefloxacin-induced cholesterogenesis and phospholipidosis in rat tissues

Overview of attention for article published in Lipids in Health and Disease, February 2015
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Title
Amoxillin- and pefloxacin-induced cholesterogenesis and phospholipidosis in rat tissues
Published in
Lipids in Health and Disease, February 2015
DOI 10.1186/s12944-015-0011-8
Pubmed ID
Authors

Solomon O Rotimi, David A Ojo, Olusola A Talabi, Regina N Ugbaja, Elizabeth A Balogun, Oladipo Ademuyiwa

Abstract

To investigate whether amoxillin and pefloxacin perturb lipid metabolism. Rats were treated with therapeutic doses of each antibiotic for 5 and 10 days respectively. Twenty four hours after the last antibiotic treatment and 5 days after antibiotic withdrawal, blood and other tissues (liver, kidney, brain, heart and spleen) were removed from the animals after an overnight fast and analysed for their lipid contents. Both antibiotics produced various degrees of compartment-specific dyslipidemia in the animals. While plasma and erythrocyte dyslipidemia was characterised by up-regulation of the concentrations of the major lipids (cholesterol, triglycerides, phospholipids and free fatty acids), hepatic and renal dyslipidemia was characterised by cholesterogenesis and phospholipidosis. Splenic dyslipidemia was characterised by cholesterogenesis and decreased phospholipid levels. Cardiac and brain cholesterol contents were not affected by the antibiotics. A transient phospholipidosis was observed in the brain whereas cardiac phospholipids decreased significantly. Lipoprotein abnormalities were reflected as down-regulation of HDL cholesterol. Furthermore, the two antibiotics increased the activity of hepatic HMG-CoA reductase. Although erythrocyte phospholipidosis was resolved 5 days after withdrawing the antibiotics, dyslipidemia observed in other compartments was still not reversible. Our findings suggest that induction of cholesterogenesis and phospholipidosis might represent additional adverse effects of amoxillin and pefloxacin.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 31 100%

Demographic breakdown

Readers by professional status Count As %
Other 4 13%
Student > Bachelor 4 13%
Lecturer > Senior Lecturer 3 10%
Student > Ph. D. Student 3 10%
Researcher 3 10%
Other 9 29%
Unknown 5 16%
Readers by discipline Count As %
Medicine and Dentistry 8 26%
Biochemistry, Genetics and Molecular Biology 6 19%
Pharmacology, Toxicology and Pharmaceutical Science 3 10%
Veterinary Science and Veterinary Medicine 2 6%
Social Sciences 2 6%
Other 6 19%
Unknown 4 13%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 February 2015.
All research outputs
#18,401,176
of 22,792,160 outputs
Outputs from Lipids in Health and Disease
#985
of 1,448 outputs
Outputs of similar age
#185,218
of 255,034 outputs
Outputs of similar age from Lipids in Health and Disease
#12
of 20 outputs
Altmetric has tracked 22,792,160 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,448 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.0. This one is in the 17th percentile – i.e., 17% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 255,034 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 20 others from the same source and published within six weeks on either side of this one. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.