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Effect of a selective neutrophil elastase inhibitor on mortality and ventilator-free days in patients with increased extravascular lung water: a post hoc analysis of the PiCCO Pulmonary Edema Study

Overview of attention for article published in Journal of Intensive Care, December 2014
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Title
Effect of a selective neutrophil elastase inhibitor on mortality and ventilator-free days in patients with increased extravascular lung water: a post hoc analysis of the PiCCO Pulmonary Edema Study
Published in
Journal of Intensive Care, December 2014
DOI 10.1186/s40560-014-0067-y
Pubmed ID
Authors

Takashi Tagami, Ryoichi Tosa, Mariko Omura, Hidetada Fukushima, Tadashi Kaneko, Tomoyuki Endo, Hiroshi Rinka, Akira Murai, Junko Yamaguchi, Kazuhide Yoshikawa, Nobuyuki Saito, Hideaki Uzu, Yoichi Kase, Makoto Takatori, Hiroo Izumino, Toshiaki Nakamura, Ryutarou Seo, Yasuhide Kitazawa, Manabu Sugita, Hiroyuki Takahashi, Yuichi Kuroki, Takayuki Irahara, Takashi Kanemura, Hiroyuki Yokota, Shigeki Kushimoto

Abstract

Neutrophil elastase plays an important role in the development and progression of acute respiratory distress syndrome (ARDS). Although the selective elastase inhibitor, sivelestat, is widely used in Japan for treating ARDS patients, its effectiveness remains controversial. The aim of the current study was to investigate the effects of sivelestat in ARDS patients with evidence of increased extravascular lung water by re-analyzing a large multicenter study database.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 62 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 62 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 15%
Researcher 8 13%
Other 6 10%
Student > Master 6 10%
Student > Bachelor 5 8%
Other 14 23%
Unknown 14 23%
Readers by discipline Count As %
Medicine and Dentistry 22 35%
Agricultural and Biological Sciences 6 10%
Biochemistry, Genetics and Molecular Biology 4 6%
Pharmacology, Toxicology and Pharmaceutical Science 3 5%
Immunology and Microbiology 3 5%
Other 7 11%
Unknown 17 27%