Title |
Effect of a selective neutrophil elastase inhibitor on mortality and ventilator-free days in patients with increased extravascular lung water: a post hoc analysis of the PiCCO Pulmonary Edema Study
|
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Published in |
Journal of Intensive Care, December 2014
|
DOI | 10.1186/s40560-014-0067-y |
Pubmed ID | |
Authors |
Takashi Tagami, Ryoichi Tosa, Mariko Omura, Hidetada Fukushima, Tadashi Kaneko, Tomoyuki Endo, Hiroshi Rinka, Akira Murai, Junko Yamaguchi, Kazuhide Yoshikawa, Nobuyuki Saito, Hideaki Uzu, Yoichi Kase, Makoto Takatori, Hiroo Izumino, Toshiaki Nakamura, Ryutarou Seo, Yasuhide Kitazawa, Manabu Sugita, Hiroyuki Takahashi, Yuichi Kuroki, Takayuki Irahara, Takashi Kanemura, Hiroyuki Yokota, Shigeki Kushimoto |
Abstract |
Neutrophil elastase plays an important role in the development and progression of acute respiratory distress syndrome (ARDS). Although the selective elastase inhibitor, sivelestat, is widely used in Japan for treating ARDS patients, its effectiveness remains controversial. The aim of the current study was to investigate the effects of sivelestat in ARDS patients with evidence of increased extravascular lung water by re-analyzing a large multicenter study database. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 62 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 9 | 15% |
Researcher | 8 | 13% |
Other | 6 | 10% |
Student > Master | 6 | 10% |
Student > Bachelor | 5 | 8% |
Other | 14 | 23% |
Unknown | 14 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 22 | 35% |
Agricultural and Biological Sciences | 6 | 10% |
Biochemistry, Genetics and Molecular Biology | 4 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 5% |
Immunology and Microbiology | 3 | 5% |
Other | 7 | 11% |
Unknown | 17 | 27% |