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Genome-wide DNA methylation analysis reveals estrogen-mediated epigenetic repression of metallothionein-1 gene cluster in breast cancer

Overview of attention for article published in Clinical Epigenetics, February 2015
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  • Above-average Attention Score compared to outputs of the same age (53rd percentile)
  • Average Attention Score compared to outputs of the same age and source

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6 X users

Citations

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39 Dimensions

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70 Mendeley
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Title
Genome-wide DNA methylation analysis reveals estrogen-mediated epigenetic repression of metallothionein-1 gene cluster in breast cancer
Published in
Clinical Epigenetics, February 2015
DOI 10.1186/s13148-015-0045-9
Pubmed ID
Authors

Rohit R Jadhav, Zhenqing Ye, Rui-Lan Huang, Joseph Liu, Pei-Yin Hsu, Yi-Wen Huang, Leticia B Rangel, Hung-Cheng Lai, Juan Carlos Roa, Nameer B Kirma, Tim Hui-Ming Huang, Victor X Jin

Abstract

Recent genome-wide analysis has shown that DNA methylation spans long stretches of chromosome regions consisting of clusters of contiguous CpG islands or gene families. Hypermethylation of various gene clusters has been reported in many types of cancer. In this study, we conducted methyl-binding domain capture (MBDCap) sequencing (MBD-seq) analysis on a breast cancer cohort consisting of 77 patients and 10 normal controls, as well as a panel of 38 breast cancer cell lines.

X Demographics

X Demographics

The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 70 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 1%
Unknown 69 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 16%
Researcher 11 16%
Student > Master 9 13%
Professor > Associate Professor 6 9%
Other 5 7%
Other 11 16%
Unknown 17 24%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 16 23%
Agricultural and Biological Sciences 15 21%
Medicine and Dentistry 6 9%
Pharmacology, Toxicology and Pharmaceutical Science 3 4%
Computer Science 3 4%
Other 4 6%
Unknown 23 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 March 2015.
All research outputs
#12,918,264
of 22,792,160 outputs
Outputs from Clinical Epigenetics
#612
of 1,251 outputs
Outputs of similar age
#115,637
of 255,548 outputs
Outputs of similar age from Clinical Epigenetics
#27
of 42 outputs
Altmetric has tracked 22,792,160 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,251 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.5. This one is in the 49th percentile – i.e., 49% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 255,548 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.
We're also able to compare this research output to 42 others from the same source and published within six weeks on either side of this one. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.